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Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.
Herster F, Bittner Z, Archer NK, Dickhöfer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Löffler MW, Kalbacher H, Vierbuchen T, Heine H, Miller LS, Hartl D, Freund L, Schäkel K, Heister M, Ghoreschi K, Weber ANR. Herster F, et al. Among authors: heine h. Nat Commun. 2020 Jan 8;11(1):105. doi: 10.1038/s41467-019-13756-4. Nat Commun. 2020. PMID: 31913271 Free PMC article.
2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.
Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T. Freund I, et al. Among authors: heine h. RNA. 2019 Jul;25(7):869-880. doi: 10.1261/rna.070243.118. Epub 2019 Apr 24. RNA. 2019. PMID: 31019095 Free PMC article.
The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.
Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA. Vierbuchen T, et al. Among authors: heine h. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213715120. doi: 10.1073/pnas.2213715120. Epub 2022 Dec 28. Proc Natl Acad Sci U S A. 2023. PMID: 36577072 Free PMC article.
WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
Brandenburg J, Marwitz S, Tazoll SC, Waldow F, Kalsdorf B, Vierbuchen T, Scholzen T, Gross A, Goldenbaum S, Hölscher A, Hein M, Linnemann L, Reimann M, Kispert A, Leitges M, Rupp J, Lange C, Niemann S, Behrends J, Goldmann T, Heine H, Schaible UE, Hölscher C, Schwudke D, Reiling N. Brandenburg J, et al. Among authors: heine h. J Clin Invest. 2021 Aug 16;131(16):e141833. doi: 10.1172/JCI141833. J Clin Invest. 2021. PMID: 34255743 Free PMC article.
412 results