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Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: tennant da. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion.
Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG. Oakey LA, et al. Among authors: tennant da. Wellcome Open Res. 2019 Sep 17;3:147. doi: 10.12688/wellcomeopenres.14898.2. eCollection 2018. Wellcome Open Res. 2019. PMID: 30607371 Free PMC article.
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Elhassan YS, et al. Among authors: tennant da. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. Cell Rep. 2019. PMID: 31412242 Free PMC article. Clinical Trial.
New aspects of amino acid metabolism in cancer.
Vettore L, Westbrook RL, Tennant DA. Vettore L, et al. Among authors: tennant da. Br J Cancer. 2020 Jan;122(2):150-156. doi: 10.1038/s41416-019-0620-5. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819187 Free PMC article. Review.
112 results