Borner T - Search Results

1

GDF15 Induces Anorexia through Nausea and Emesis.

Borner T, Shaulson ED, Ghidewon MY, Barnett AB, Horn CC, Doyle RP, Grill HJ, Hayes MR, De Jonghe BC. Borner T, et al. Cell Metab. 2020 Feb 4;31(2):351-362.e5. doi: 10.1016/j.cmet.2019.12.004. Epub 2020 Jan 9. Cell Metab. 2020. PMID: 31928886 Free PMC article.

2

A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents.

Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, Reiner DJ, Koch-Laskowski K, McGrath LE, Lhamo R, Stein LM, De Jonghe BC, Holz GG, Roth CL, Doyle RP, Hayes MR. Mietlicki-Baase EG, et al. Among authors: borner t. Diabetes Obes Metab. 2018 May;20(5):1223-1234. doi: 10.1111/dom.13222. Epub 2018 Feb 20. Diabetes Obes Metab. 2018. PMID: 29327400 Free PMC article.

3

Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation.

Leon RM, Borner T, Reiner DJ, Stein LM, Lhamo R, De Jonghe BC, Hayes MR. Leon RM, et al. Among authors: borner t. Neuropsychopharmacology. 2019 Sep;44(10):1742-1751. doi: 10.1038/s41386-019-0384-x. Epub 2019 Apr 8. Neuropsychopharmacology. 2019. PMID: 30959513 Free PMC article.

4

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.

Fortin SM, Lipsky RK, Lhamo R, Chen J, Kim E, Borner T, Schmidt HD, Hayes MR. Fortin SM, et al. Among authors: borner t. Sci Transl Med. 2020 Mar 4;12(533):eaay8071. doi: 10.1126/scitranslmed.aay8071. Sci Transl Med. 2020. PMID: 32132220 Free PMC article.

5

GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.

Borner T, Wald HS, Ghidewon MY, Zhang B, Wu Z, De Jonghe BC, Breen D, Grill HJ. Borner T, et al. Cell Rep. 2020 Apr 21;31(3):107543. doi: 10.1016/j.celrep.2020.107543. Cell Rep. 2020. PMID: 32320650 Free PMC article.

6

A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models.

Borner T, Shaulson ED, Tinsley IC, Stein LM, Horn CC, Hayes MR, Doyle RP, De Jonghe BC. Borner T, et al. Diabetes Obes Metab. 2020 Oct;22(10):1729-1741. doi: 10.1111/dom.14089. Epub 2020 Jun 25. Diabetes Obes Metab. 2020. PMID: 32410372 Free PMC article.

7

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis.

Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, Chepurny OG, Holz GG, Wierzba AJ, Gryko D, Nexø E, Shaulson ED, Bamezai A, Da Silva VAR, De Jonghe BC, Hayes MR, Doyle RP. Borner T, et al. Cell Rep. 2020 Jun 16;31(11):107768. doi: 10.1016/j.celrep.2020.107768. Cell Rep. 2020. PMID: 32553160 Free PMC article.

8

Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.

Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, Hayes MR, De Jonghe BC, Holz GG, Roth CL, Doyle RP. Milliken BT, et al. Among authors: borner t. J Med Chem. 2021 Jan 28;64(2):1127-1138. doi: 10.1021/acs.jmedchem.0c01783. Epub 2021 Jan 15. J Med Chem. 2021. PMID: 33449689 Free PMC article.

9

Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats.

Leon RM, Borner T, Stein LM, Urrutia NA, De Jonghe BC, Schmidt HD, Hayes MR. Leon RM, et al. Among authors: borner t. Neuropharmacology. 2021 Apr 1;187:108477. doi: 10.1016/j.neuropharm.2021.108477. Epub 2021 Feb 10. Neuropharmacology. 2021. PMID: 33581143 Free PMC article.

10

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4.

Tinsley IC, Borner T, Swanson ML, Chepurny OG, Doebley SA, Kamat V, Sweet IR, Holz GG, Hayes MR, De Jonghe BC, Doyle RP. Tinsley IC, et al. Among authors: borner t. J Med Chem. 2021 Mar 25;64(6):3479-3492. doi: 10.1021/acs.jmedchem.1c00185. Epub 2021 Mar 6. J Med Chem. 2021. PMID: 33677970 Free PMC article.

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