Chung WK - Search Results

1

Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Swope N, Chung WK, Cao M, Motabar D, Liu D, Ahuja S, Handlogten M. Swope N, et al. Among authors: chung wk. Biotechnol Bioeng. 2020 Apr;117(4):1063-1071. doi: 10.1002/bit.27264. Epub 2020 Jan 23. Biotechnol Bioeng. 2020. PMID: 31930476 Free PMC article.

2

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability.

Chung WK, Russell B, Yang Y, Handlogten M, Hudak S, Cao M, Wang J, Robbins D, Ahuja S, Zhu M. Chung WK, et al. Biotechnol Bioeng. 2017 Jun;114(6):1264-1274. doi: 10.1002/bit.26265. Epub 2017 Mar 6. Biotechnol Bioeng. 2017. PMID: 28186329 Free PMC article.

3

Characterization and analysis of scFv-IgG bispecific antibody size variants.

Cao M, Wang C, Chung WK, Motabar D, Wang J, Christian E, Lin S, Hunter A, Wang X, Liu D. Cao M, et al. Among authors: chung wk. MAbs. 2018 Nov-Dec;10(8):1236-1247. doi: 10.1080/19420862.2018.1505398. Epub 2018 Sep 20. MAbs. 2018. PMID: 30130449 Free PMC article.

4

An Integrated Approach to Aggregate Control for Therapeutic Bispecific Antibodies Using an Improved Three Column Mab Platform-Like Purification Process.

Andrade C, Arnold L, Motabar D, Aspelund M, Tang A, Hunter A, Chung WK. Andrade C, et al. Among authors: chung wk. Biotechnol Prog. 2019 Jan;35(1):e2720. doi: 10.1002/btpr.2720. Epub 2018 Oct 17. Biotechnol Prog. 2019. PMID: 30298991 Free PMC article.

5

Systematic workflow for studying domain contributions of bispecific antibodies to selectivity in multimodal chromatography.

Parasnavis SS, Niu B, Aspelund M, Chung WK, Snyder M, Cramer SM. Parasnavis SS, et al. Among authors: chung wk. Biotechnol Bioeng. 2022 Jan;119(1):211-225. doi: 10.1002/bit.27967. Epub 2021 Nov 2. Biotechnol Bioeng. 2022. PMID: 34687215

6

Investigation of cathepsin D-mAb interactions using a combined experimental and computational tool set.

Ranjan S, Chung WK, Hofele R, Heidbrink Thompson J, Bee J, Zhang L, Robbins D, Cramer SM. Ranjan S, et al. Among authors: chung wk. Biotechnol Bioeng. 2019 Jul;116(7):1684-1697. doi: 10.1002/bit.26968. Epub 2019 Mar 29. Biotechnol Bioeng. 2019. PMID: 30882893

7

A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies.

Aboulaich N, Chung WK, Thompson JH, Larkin C, Robbins D, Zhu M. Aboulaich N, et al. Among authors: chung wk. Biotechnol Prog. 2014 Sep-Oct;30(5):1114-24. doi: 10.1002/btpr.1948. Epub 2014 Jul 26. Biotechnol Prog. 2014. PMID: 25044920 Free PMC article.

8

Implementation of an experimental and computational tool set to study protein-mAb interactions.

Ranjan S, Chung WK, Zhu M, Robbins D, Cramer SM. Ranjan S, et al. Among authors: chung wk. Biotechnol Prog. 2019 Jul;35(4):e2825. doi: 10.1002/btpr.2825. Epub 2019 May 13. Biotechnol Prog. 2019. PMID: 31017347

9

Improved detection of host cell proteins (HCPs) in a mammalian cell-derived antibody drug using liquid chromatography/mass spectrometry in conjunction with an HCP-enrichment strategy.

Thompson JH, Chung WK, Zhu M, Tie L, Lu Y, Aboulaich N, Strouse R, Mo WD. Thompson JH, et al. Among authors: chung wk. Rapid Commun Mass Spectrom. 2014 Apr 30;28(8):855-60. doi: 10.1002/rcm.6854. Rapid Commun Mass Spectrom. 2014. PMID: 24623688

10

Investigation of protein binding affinity and preferred orientations in ion exchange systems using a homologous protein library.

Chung WK, Hou Y, Freed A, Holstein M, Makhatadze GI, Cramer SM. Chung WK, et al. Biotechnol Bioeng. 2009 Feb 15;102(3):869-81. doi: 10.1002/bit.22100. Biotechnol Bioeng. 2009. PMID: 18821632

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