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The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.
Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA. Xu Y, et al. Among authors: plant ld. J Biol Chem. 2020 Mar 13;295(11):3614-3634. doi: 10.1074/jbc.RA119.011527. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953327 Free PMC article.
PIP2 regulation of TRPC5 channel activation and desensitization.
Ningoo M, Plant LD, Greka A, Logothetis DE. Ningoo M, et al. Among authors: plant ld. J Biol Chem. 2021 Jan-Jun;296:100726. doi: 10.1016/j.jbc.2021.100726. Epub 2021 Apr 30. J Biol Chem. 2021. PMID: 33933453 Free PMC article.
A molecular switch controls the impact of cholesterol on a Kir channel.
Corradi V, Bukiya AN, Miranda WE, Cui M, Plant LD, Logothetis DE, Tieleman DP, Noskov SY, Rosenhouse-Dantsker A. Corradi V, et al. Among authors: plant ld. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2109431119. doi: 10.1073/pnas.2109431119. Epub 2022 Mar 25. Proc Natl Acad Sci U S A. 2022. PMID: 35333652 Free PMC article.
A novel small-molecule selective activator of homomeric GIRK4 channels.
Cui M, Xu K, Gada KD, Shalomov B, Ban M, Eptaminitaki GC, Kawano T, Plant LD, Dascal N, Logothetis DE. Cui M, et al. Among authors: plant ld. J Biol Chem. 2022 Jun;298(6):102009. doi: 10.1016/j.jbc.2022.102009. Epub 2022 May 4. J Biol Chem. 2022. PMID: 35525275 Free PMC article.
Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramer.
De Oliveira PA, Moreno E, Casajuana-Martin N, Casadó-Anguera V, Cai NS, Camacho-Hernandez GA, Zhu H, Bonifazi A, Hall MD, Weinshenker D, Newman AH, Logothetis DE, Casadó V, Plant LD, Pardo L, Ferré S. De Oliveira PA, et al. Among authors: plant ld. Pharmacol Res. 2022 Aug;182:106322. doi: 10.1016/j.phrs.2022.106322. Epub 2022 Jun 22. Pharmacol Res. 2022. PMID: 35750299 Free PMC article.
60 results