Okumura N - Search Results

1

Heterozygous variant fibrinogen γA289V (Kanazawa III) was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens.

Kaido T, Yoda M, Kamijo T, Taira C, Higuchi Y, Okumura N. Kaido T, et al. Among authors: okumura n. Int J Lab Hematol. 2020 Apr;42(2):190-197. doi: 10.1111/ijlh.13152. Epub 2020 Jan 20. Int J Lab Hematol. 2020. PMID: 31957968

2

Quantitative RT-PCR analysis demonstrates that synthesis of the recombinant fibrinogen is dependent on the transcription and synthesis of gamma-chain.

Hirota-Kawadobora M, Tozuka M, Yamauchi K, Hidaka E, Ueno I, Sugano M, Terasawa F, Okumura N, Katsuyama T, Shigematsu H. Hirota-Kawadobora M, et al. Among authors: okumura n. Clin Chim Acta. 2002 May 7;319(1):67-73. doi: 10.1016/s0009-8981(02)00022-0. Clin Chim Acta. 2002. PMID: 11922926

3

Analysis of fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein.

Okumura N, Terasawa F, Tanaka H, Hirota M, Ota H, Kitano K, Kiyosawa K, Lord ST. Okumura N, et al. Blood. 2002 May 15;99(10):3654-60. doi: 10.1182/blood.v99.10.3654. Blood. 2002. PMID: 11986220 Free article.

4

Evidence that heterodimers exist in the fibrinogen Matsumoto II (gamma308N-->K) proband and participate in fibrin fiber formation.

Okumura N, Terasawa F, Fujita K, Fujihara N, Tozuka M, Koh CS. Okumura N, et al. Thromb Res. 2002 Aug 15;107(3-4):157-62. doi: 10.1016/s0049-3848(02)00253-0. Thromb Res. 2002. PMID: 12431483

5

In vitro expression demonstrates impaired secretion of the gammaAsn319, Asp320 deletion variant fibrinogen.

Kani S, Terasawa F, Lord ST, Tozuka M, Ota H, Okumura N, Katsuyama T. Kani S, et al. Among authors: okumura n. Thromb Haemost. 2005 Jul;94(1):53-9. doi: 10.1160/TH05-02-0134. Thromb Haemost. 2005. PMID: 16113784

6

In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gammaAsn319, Asp320 deletion dysfibrinogen, Otsu I.

Terasawa F, Kani S, Hongo M, Okumura N. Terasawa F, et al. Among authors: okumura n. Thromb Res. 2006;118(5):651-61. doi: 10.1016/j.thromres.2005.10.013. Epub 2006 Jan 10. Thromb Res. 2006. PMID: 16412498

7

Analysis of fibrinogen variants at gamma387Ile shows that the side chain of gamma387 and the tertiary structure of the gammaC-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation.

Kani S, Terasawa F, Yamauchi K, Tozuka M, Okumura N. Kani S, et al. Among authors: okumura n. Blood. 2006 Sep 15;108(6):1887-94. doi: 10.1182/blood-2006-04-016485. Epub 2006 May 16. Blood. 2006. PMID: 16705085 Free article.

8

[Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency].

Hirota-Kawadobora M, Ishikawa S, Fujihara N, Wakabayashi S, Kamijo Y, Yamauchi K, Terasawa F, Okumura N, Katsuyama T. Hirota-Kawadobora M, et al. Among authors: okumura n. Rinsho Byori. 2007 Nov;55(11):989-95. Rinsho Byori. 2007. PMID: 18154029 Japanese.

9

Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.

Haneishi A, Terasawa F, Fujihara N, Yamauchi K, Okumura N, Katsuyama T. Haneishi A, et al. Among authors: okumura n. Thromb Res. 2009 Jul;124(3):368-72. doi: 10.1016/j.thromres.2009.03.011. Epub 2009 May 6. Thromb Res. 2009. PMID: 19419756

10

[Functional analysis of heterozygous plasma dysfibrinogens derived from two families of gammaArg275Cys and three families of gammaArg275His, and haplotype analysis for these families].

Kamijyo Y, Hirota-Kawadobora M, Fujihara N, Wakabayashi S, Matsuda K, Yamauchi K, Terasawa F, Okumura N, Honda T. Kamijyo Y, et al. Among authors: okumura n. Rinsho Byori. 2009 Jul;57(7):651-8. Rinsho Byori. 2009. PMID: 19708534 Japanese.

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