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Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, Nikolovska-Coleska Z. Kump KJ, et al. Among authors: khanna m. J Med Chem. 2020 Mar 12;63(5):2489-2510. doi: 10.1021/acs.jmedchem.9b01442. Epub 2020 Feb 14. J Med Chem. 2020. PMID: 31971799 Free PMC article.
An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.
Mollasalehi N, Francois-Moutal L, Scott DD, Tello JA, Williams H, Mahoney B, Carlson JM, Dong Y, Li X, Miranda VG, Gokhale V, Wang W, Barmada SJ, Khanna M. Mollasalehi N, et al. Among authors: khanna m. ACS Chem Biol. 2020 Nov 20;15(11):2854-2859. doi: 10.1021/acschembio.0c00494. Epub 2020 Oct 12. ACS Chem Biol. 2020. PMID: 33044808 Free PMC article.
In Silico Targeting of the Long Noncoding RNA MALAT1.
François-Moutal L, Miranda VG, Mollasalehi N, Gokhale V, Khanna M. François-Moutal L, et al. Among authors: khanna m. ACS Med Chem Lett. 2021 Apr 1;12(6):915-921. doi: 10.1021/acsmedchemlett.1c00060. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141069 Free PMC article.
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.
Wang F, Li J, Sinn AL, Knabe WE, Khanna M, Jo I, Silver JM, Oh K, Li L, Sandusky GE, Sledge GW, Nakshatri H, Jones DR, Pollok KE, Meroueh SO. Wang F, et al. Among authors: khanna m. J Med Chem. 2011 Oct 27;54(20):7193-205. doi: 10.1021/jm200782y. Epub 2011 Oct 4. J Med Chem. 2011. PMID: 21851064 Free PMC article.
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
François-Moutal L, Scott DD, Ambrose AJ, Zerio CJ, Rodriguez-Sanchez M, Dissanayake K, May DG, Carlson JM, Barbieri E, Moutal A, Roux KJ, Shorter J, Khanna R, Barmada SJ, McGurk L, Khanna M. François-Moutal L, et al. Among authors: khanna r, khanna m. Sci Rep. 2022 May 17;12(1):8140. doi: 10.1038/s41598-022-12191-8. Sci Rep. 2022. PMID: 35581326 Free PMC article.
Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.
Mani T, Wang F, Knabe WE, Sinn AL, Khanna M, Jo I, Sandusky GE, Sledge GW Jr, Jones DR, Khanna R, Pollok KE, Meroueh SO. Mani T, et al. Among authors: khanna r, khanna m. Bioorg Med Chem. 2013 Apr 1;21(7):2145-55. doi: 10.1016/j.bmc.2012.12.047. Epub 2013 Jan 9. Bioorg Med Chem. 2013. PMID: 23411397 Free PMC article.
(-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels.
Cai S, Bellampalli SS, Yu J, Li W, Ji Y, Wijeratne EMK, Dorame A, Luo S, Shan Z, Khanna M, Moutal A, Streicher JM, Gunatilaka AAL, Khanna R. Cai S, et al. Among authors: khanna r, khanna m. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. doi: 10.1021/acschemneuro.8b00617. Epub 2018 Dec 20. ACS Chem Neurosci. 2019. PMID: 30525440
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
François-Moutal L, Felemban R, Scott DD, Sayegh MR, Miranda VG, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M. François-Moutal L, et al. Among authors: khanna r, khanna m. ACS Chem Biol. 2019 Sep 20;14(9):2006-2013. doi: 10.1021/acschembio.9b00481. Epub 2019 Aug 27. ACS Chem Biol. 2019. PMID: 31241884 Free PMC article.
498 results