Qin Y - Search Results

1

Roflupram exerts neuroprotection via activation of CREB/PGC-1α signalling in experimental models of Parkinson's disease.

Zhong J, Dong W, Qin Y, Xie J, Xiao J, Xu J, Wang H. Zhong J, et al. Among authors: qin y. Br J Pharmacol. 2020 May;177(10):2333-2350. doi: 10.1111/bph.14983. Epub 2020 Feb 26. Br J Pharmacol. 2020. PMID: 31972868 Free PMC article.

2

Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.

Dong WL, Zhong JH, Chen YQ, Xie JF, Qin YY, Xu JP, Cai NB, Li MF, Liu L, Wang HT. Dong WL, et al. Acta Pharmacol Sin. 2021 Dec;42(12):1991-2003. doi: 10.1038/s41401-021-00768-4. Epub 2021 Sep 16. Acta Pharmacol Sin. 2021. PMID: 34531546 Free PMC article.

3

FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β/ β-catenin signaling pathway.

Xu B, Wang T, Xiao J, Dong W, Wen HZ, Wang X, Qin Y, Cai N, Zhou Z, Xu J, Wang H. Xu B, et al. Among authors: qin y. Biochem Pharmacol. 2019 May;163:234-249. doi: 10.1016/j.bcp.2019.02.023. Epub 2019 Feb 21. Biochem Pharmacol. 2019. PMID: 30797872

4

Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway.

Li D, Xu J, Qin Y, Cai N, Cheng Y, Wang H. Li D, et al. Among authors: qin y. Int Immunopharmacol. 2021 Jan;90:107176. doi: 10.1016/j.intimp.2020.107176. Epub 2020 Nov 23. Int Immunopharmacol. 2021. PMID: 33243606

5

Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.

Zhong J, Li M, Xu J, Dong W, Qin Y, Qiu S, Li X, Wang H. Zhong J, et al. Among authors: qin y. Toxicol Appl Pharmacol. 2022 Feb 1;436:115859. doi: 10.1016/j.taap.2021.115859. Epub 2022 Jan 4. Toxicol Appl Pharmacol. 2022. PMID: 34990728

6

Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway.

Xu B, Qin Y, Li D, Cai N, Wu J, Jiang L, Jie L, Zhou Z, Xu J, Wang H. Xu B, et al. Among authors: qin y. Redox Biol. 2020 Jan;28:101342. doi: 10.1016/j.redox.2019.101342. Epub 2019 Oct 13. Redox Biol. 2020. PMID: 31639651 Free PMC article.

7

Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress.

Xie J, Bi B, Qin Y, Dong W, Zhong J, Li M, Cheng Y, Xu J, Wang H. Xie J, et al. Among authors: qin y. Brain Behav Immun. 2021 Feb;92:67-77. doi: 10.1016/j.bbi.2020.11.029. Epub 2020 Nov 20. Brain Behav Immun. 2021. PMID: 33221489

8

Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 pathway.

Cai N, Xu B, Li X, Qin Y, Li M, Chen K, Xu J, Wang H. Cai N, et al. Among authors: qin y. Eur J Pharmacol. 2022 Jul 5;926:175027. doi: 10.1016/j.ejphar.2022.175027. Epub 2022 May 13. Eur J Pharmacol. 2022. PMID: 35569548

9

Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway.

Xu B, Xu J, Cai N, Li M, Liu L, Qin Y, Li X, Wang H. Xu B, et al. Among authors: qin y. Free Radic Biol Med. 2021 Feb 1;163:281-296. doi: 10.1016/j.freeradbiomed.2020.12.018. Epub 2020 Dec 24. Free Radic Biol Med. 2021. PMID: 33359910

10

Identification of Proteoforms Related to Nelumbo nucifera Flower Petaloid Through Proteogenomic Strategy.

Lin Z, Shu J, Qin Y, Cao D, Deng J, Yang P. Lin Z, et al. Among authors: qin y. Proteomes. 2025 Jan 15;13(1):4. doi: 10.3390/proteomes13010004. Proteomes. 2025. PMID: 39846635

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