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Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity.
Ho SK, Xu Z, Thakur A, Fox M, Tan SS, DiGiammarino E, Zhou L, Sho M, Cairns B, Zhao V, Xiong M, Samayoa J, Forsyth CM, Powers DB, Chao DT, Hollenbaugh D, Alvarez HM, Akamatsu Y. Ho SK, et al. Among authors: akamatsu y. Mol Cancer Ther. 2020 Apr;19(4):1040-1051. doi: 10.1158/1535-7163.MCT-19-0608. Epub 2020 Jan 23. Mol Cancer Ther. 2020. PMID: 31974274
An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Chan S, Belmar N, Ho S, Rogers B, Stickler M, Graham M, Lee E, Tran N, Zhang D, Gupta P, Sho M, MacDonough T, Woolley A, Kim H, Zhang H, Liu W, Zheng P, Dezso Z, Halliwill K, Ceccarelli M, Rhodes S, Thakur A, Forsyth CM, Xiong M, Tan SS, Iyer R, Lake M, Digiammarino E, Zhou L, Bigelow L, Longenecker K, Judge RA, Liu C, Trumble M, Remis JP, Fox M, Cairns B, Akamatsu Y, Hollenbaugh D, Harding F, Alvarez HM. Chan S, et al. Among authors: akamatsu y. Nat Cancer. 2022 Mar;3(3):337-354. doi: 10.1038/s43018-022-00334-9. Epub 2022 Mar 7. Nat Cancer. 2022. PMID: 35256819 Free PMC article.
CTLA4-Ig-Based Bifunctional Costimulation Inhibitor Blocks CD28 and ICOS Signaling to Prevent T Cell Priming and Effector Function.
Goenka R, Xu Z, Samayoa J, Banach D, Beam C, Bose S, Dooner G, Forsyth CM, Lu X, Medina L, Sadhukhan R, Sielaff B, Sousa S, Tao Q, Touw D, Wu F, Kingsbury GA, Akamatsu Y. Goenka R, et al. Among authors: akamatsu y. J Immunol. 2021 Mar 1;206(5):1102-1113. doi: 10.4049/jimmunol.2001100. Epub 2021 Jan 25. J Immunol. 2021. PMID: 33495237
483 results