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Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, Cox MB, Chaudhary J, Gestwicki JE, Balch WE. Singh JK, et al. Among authors: balch we. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6. doi: 10.1016/j.chembiol.2020.01.008. Epub 2020 Feb 3. Cell Chem Biol. 2020. PMID: 32017918 Free PMC article.
The proteostasis boundary in misfolding diseases of membrane traffic.
Hutt DM, Powers ET, Balch WE. Hutt DM, et al. Among authors: balch we. FEBS Lett. 2009 Aug 20;583(16):2639-46. doi: 10.1016/j.febslet.2009.07.014. FEBS Lett. 2009. PMID: 19708088 Free PMC article. Review.
Protein function is regulated by the proteostasis network (PN) [Balch, W.E., Morimoto, R.I., Dillin, A. and Kelly, J.W. (2008) Adapting proteostasis for disease intervention. ...We emphasize the enabling principle of a 'proteostasis boundary (PB)' [Powers, E.T., Mor …
Protein function is regulated by the proteostasis network (PN) [Balch, W.E., Morimoto, R.I., Dillin, A. and Kelly, J.W. (2008) Adapti …
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE. Hutt DM, et al. Among authors: balch we. Nat Chem Biol. 2010 Jan;6(1):25-33. doi: 10.1038/nchembio.275. Epub 2009 Dec 6. Nat Chem Biol. 2010. PMID: 19966789 Free PMC article.
245 results