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Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.
Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S. Bottai D, et al. Among authors: sayes f. Mol Microbiol. 2012 Mar;83(6):1195-209. doi: 10.1111/j.1365-2958.2012.08001.x. Epub 2012 Feb 20. Mol Microbiol. 2012. PMID: 22340629 Free article.
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis.
Supply P, Marceau M, Mangenot S, Roche D, Rouanet C, Khanna V, Majlessi L, Criscuolo A, Tap J, Pawlik A, Fiette L, Orgeur M, Fabre M, Parmentier C, Frigui W, Simeone R, Boritsch EC, Debrie AS, Willery E, Walker D, Quail MA, Ma L, Bouchier C, Salvignol G, Sayes F, Cascioferro A, Seemann T, Barbe V, Locht C, Gutierrez MC, Leclerc C, Bentley SD, Stinear TP, Brisse S, Médigue C, Parkhill J, Cruveiller S, Brosch R. Supply P, et al. Among authors: sayes f. Nat Genet. 2013 Feb;45(2):172-9. doi: 10.1038/ng.2517. Epub 2013 Jan 6. Nat Genet. 2013. PMID: 23291586 Free PMC article.
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis.
Majlessi L, Sayes F, Bureau JF, Pawlik A, Michel V, Jouvion G, Huerre M, Severgnini M, Consolandi C, Peano C, Brosch R, Touati E, Leclerc C. Majlessi L, et al. Among authors: sayes f. Mucosal Immunol. 2017 Sep;10(5):1178-1189. doi: 10.1038/mi.2016.140. Epub 2017 Feb 1. Mucosal Immunol. 2017. PMID: 28145441 Free article.
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection.
Gröschel MI, Sayes F, Shin SJ, Frigui W, Pawlik A, Orgeur M, Canetti R, Honoré N, Simeone R, van der Werf TS, Bitter W, Cho SN, Majlessi L, Brosch R. Gröschel MI, et al. Among authors: sayes f. Cell Rep. 2017 Mar 14;18(11):2752-2765. doi: 10.1016/j.celrep.2017.02.057. Cell Rep. 2017. PMID: 28297677 Free article.
40 results