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A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.
Evison BJ, Palmer JT, Lambert G, Treutlein H, Zeng J, Nativel B, Chemello K, Zhu Q, Wang J, Teng Y, Tang W, Xu Y, Rathi AK, Kumar S, Suchowerska AK, Parmar J, Dixon I, Kelly GE, Bonnar J. Evison BJ, et al. Among authors: lambert g. Bioorg Med Chem. 2020 Mar 15;28(6):115344. doi: 10.1016/j.bmc.2020.115344. Epub 2020 Jan 31. Bioorg Med Chem. 2020. PMID: 32051094 Free article.
PCSK9: from biology to clinical applications.
Blanchard V, Khantalin I, Ramin-Mangata S, Chémello K, Nativel B, Lambert G. Blanchard V, et al. Among authors: lambert g. Pathology. 2019 Feb;51(2):177-183. doi: 10.1016/j.pathol.2018.10.012. Epub 2018 Dec 4. Pathology. 2019. PMID: 30522786 Review.
Heart to heart with PCSK9.
Chemello K, Jaafar AK, Lambert G. Chemello K, et al. Among authors: lambert g. Eur Heart J. 2021 Aug 21;42(32):3091-3093. doi: 10.1093/eurheartj/ehab480. Eur Heart J. 2021. PMID: 34324660 No abstract available.
A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo.
Suchowerska AK, Stokman G, Palmer JT, Coghlan PA, Pieterman EJ, Keijzer N, Lambert G, Chemello K, Jaafar AK, Parmar J, Yan L, Tong Y, Mu L, Princen HMG, Bonnar J, Evison BJ. Suchowerska AK, et al. Among authors: lambert g. J Lipid Res. 2022 Nov;63(11):100293. doi: 10.1016/j.jlr.2022.100293. Epub 2022 Oct 6. J Lipid Res. 2022. PMID: 36209894 Free PMC article.
PCSK9 inhibition for autosomal recessive hypercholesterolemia.
Chemello K, Martín C, Lambert G. Chemello K, et al. Among authors: lambert g. Atherosclerosis. 2019 May;284:209-211. doi: 10.1016/j.atherosclerosis.2019.02.013. Epub 2019 Feb 23. Atherosclerosis. 2019. PMID: 30862376 No abstract available.
Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor): Implications for the Efficacy of Evolocumab.
Thedrez A, Blom DJ, Ramin-Mangata S, Blanchard V, Croyal M, Chemello K, Nativel B, Pichelin M, Cariou B, Bourane S, Tang L, Farnier M, Raal FJ, Lambert G. Thedrez A, et al. Among authors: lambert g. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):592-598. doi: 10.1161/ATVBAHA.117.310217. Epub 2017 Dec 28. Arterioscler Thromb Vasc Biol. 2018. PMID: 29284604 Free PMC article. Clinical Trial.
Lipoprotein metabolism in familial hypercholesterolemia.
Chemello K, García-Nafría J, Gallo A, Martín C, Lambert G, Blom D. Chemello K, et al. Among authors: lambert g. J Lipid Res. 2021;62:100062. doi: 10.1016/j.jlr.2021.100062. Epub 2021 Mar 3. J Lipid Res. 2021. PMID: 33675717 Free PMC article. Review.
PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate.
Croyal M, Tran TT, Blanchard RH, Le Bail JC, Villard EF, Poirier B, Aguesse A, Billon-Crossouard S, Ramin-Mangata S, Blanchard V, Nativel B, Chemello K, Khantalin I, Thedrez A, Janiak P, Krempf M, Boixel C, Lambert G, Guillot E. Croyal M, et al. Among authors: lambert g. Clin Sci (Lond). 2018 May 31;132(10):1075-1083. doi: 10.1042/CS20180040. Print 2018 May 31. Clin Sci (Lond). 2018. PMID: 29724769
1,309 results