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Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.
Kim MJ, Jeong ES, Park JS, Lee SJ, Ghim JL, Choi CS, Shin JG, Kim DH. Kim MJ, et al. Among authors: ghim jl. Drug Metab Dispos. 2014 Jan;42(1):141-52. doi: 10.1124/dmd.113.053017. Epub 2013 Oct 29. Drug Metab Dispos. 2014. PMID: 24170778
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