Hsu KC - Search Results

1

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.

Ojha R, Nepali K, Chen CH, Chuang KH, Wu TY, Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP. Ojha R, et al. Among authors: hsu kc. Eur J Med Chem. 2020 Mar 15;190:112086. doi: 10.1016/j.ejmech.2020.112086. Epub 2020 Jan 23. Eur J Med Chem. 2020. PMID: 32058238

2

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.

Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC. Chu CH, et al. Among authors: hsu kc. J Med Chem. 2014 Jul 24;57(14):5975-85. doi: 10.1021/jm500249n. Epub 2014 Jul 9. J Med Chem. 2014. PMID: 24971742 Free PMC article.

3

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors.

Das A, Adak AK, Ponnapalli K, Lin CH, Hsu KC, Yang JM, Hsu TA, Lin CC. Das A, et al. Among authors: hsu ta, hsu kc. Eur J Med Chem. 2016 Nov 10;123:397-406. doi: 10.1016/j.ejmech.2016.07.064. Epub 2016 Jul 28. Eur J Med Chem. 2016. PMID: 27487569

4

Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES).

Huang KW, Hsu KC, Chu LY, Yang JM, Yuan HS, Hsiao YY. Huang KW, et al. Among authors: hsu kc. J Med Chem. 2016 Sep 8;59(17):8019-29. doi: 10.1021/acs.jmedchem.6b00794. Epub 2016 Aug 29. J Med Chem. 2016. PMID: 27529560

5

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells.

Chao MW, Huang HL, HuangFu WC, Hsu KC, Liu YM, Wu YW, Lin CF, Chen YL, Lai MJ, Lee HY, Liou JP, Teng CM, Yang CR. Chao MW, et al. Among authors: hsu kc. Oncotarget. 2017 Apr 25;8(17):27772-27785. doi: 10.18632/oncotarget.15115. Oncotarget. 2017. PMID: 28186963 Free PMC article.

6

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach.

Hsu KC, Liu CY, Lin TE, Hsieh JH, Sung TY, Tseng HJ, Yang JM, Huang WJ. Hsu KC, et al. Sci Rep. 2017 Jun 12;7(1):3228. doi: 10.1038/s41598-017-03417-1. Sci Rep. 2017. PMID: 28607401 Free PMC article.

7

Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer.

Chen CH, Changou CA, Hsieh TH, Lee YC, Chu CY, Hsu KC, Wang HC, Lin YC, Lo YN, Liu YR, Liou JP, Yen Y. Chen CH, et al. Among authors: hsu kc. Clin Cancer Res. 2018 Mar 1;24(5):1176-1189. doi: 10.1158/1078-0432.CCR-17-2066. Epub 2017 Dec 8. Clin Cancer Res. 2018. PMID: 29222162

8

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities.

Chao SW, Chen LC, Yu CC, Liu CY, Lin TE, Guh JH, Wang CY, Chen CY, Hsu KC, Huang WJ. Chao SW, et al. Among authors: hsu kc. Eur J Med Chem. 2018 Jan 1;143:792-805. doi: 10.1016/j.ejmech.2017.11.092. Epub 2017 Dec 5. Eur J Med Chem. 2018. PMID: 29223096

9

A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo.

Wu YW, Hsu KC, Lee HY, Huang TC, Lin TE, Chen YL, Sung TY, Liou JP, Hwang-Verslues WW, Pan SL, HuangFu WC. Wu YW, et al. Among authors: hsu kc. Front Pharmacol. 2018 Mar 13;9:205. doi: 10.3389/fphar.2018.00205. eCollection 2018. Front Pharmacol. 2018. PMID: 29593536 Free PMC article.

10

Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation.

Chen LC, Tseng HJ, Liu CY, Huang YY, Yen CC, Weng JR, Lu YL, Hou WC, Lin TE, Pan IH, Huang KK, Huang WJ, Hsu KC. Chen LC, et al. Among authors: hsu kc. Front Pharmacol. 2018 Jul 3;9:708. doi: 10.3389/fphar.2018.00708. eCollection 2018. Front Pharmacol. 2018. PMID: 30018556 Free PMC article.

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