Lambert NA - Search Results

1

Structure of formylpeptide receptor 2-G_i complex reveals insights into ligand recognition and signaling.

Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C. Zhuang Y, et al. Among authors: lambert na. Nat Commun. 2020 Feb 14;11(1):885. doi: 10.1038/s41467-020-14728-9. Nat Commun. 2020. PMID: 32060286 Free PMC article.

2

Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers.

Qin K, Dong C, Wu G, Lambert NA. Qin K, et al. Among authors: lambert na. Nat Chem Biol. 2011 Aug 28;7(10):740-7. doi: 10.1038/nchembio.642. Nat Chem Biol. 2011. PMID: 21873996 Free PMC article.

3

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.

Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, Marti-Solano M, Rodríguez D, Hot B, Okashah N, Strakova K, Valnohova J, Babu MM, Lambert NA, Carlsson J, Schulte G. Wright SC, et al. Among authors: lambert na. Nat Commun. 2019 Feb 8;10(1):667. doi: 10.1038/s41467-019-08630-2. Nat Commun. 2019. PMID: 30737406 Free PMC article.

4

Common activation mechanism of class A GPCRs.

Zhou Q, Yang D, Wu M, Guo Y, Guo W, Zhong L, Cai X, Dai A, Jang W, Shakhnovich EI, Liu ZJ, Stevens RC, Lambert NA, Babu MM, Wang MW, Zhao S. Zhou Q, et al. Among authors: lambert na. Elife. 2019 Dec 19;8:e50279. doi: 10.7554/eLife.50279. Elife. 2019. PMID: 31855179 Free PMC article.

5

Components of the G_s signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β₂ -adrenergic receptor activation.

Bondar A, Jang W, Sviridova E, Lambert NA. Bondar A, et al. Among authors: lambert na. Traffic. 2020 Apr;21(4):324-332. doi: 10.1111/tra.12724. Traffic. 2020. PMID: 32096320 Free PMC article.

6

An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling.

Jang W, Adams CE, Liu H, Zhang C, Levy FO, Andressen KW, Lambert NA. Jang W, et al. Among authors: lambert na. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30755-30762. doi: 10.1073/pnas.2010801117. Epub 2020 Nov 16. Proc Natl Acad Sci U S A. 2020. PMID: 33199589 Free PMC article.

7

Constitutive G protein coupling profiles of understudied orphan GPCRs.

Lu S, Jang W, Inoue A, Lambert NA. Lu S, et al. Among authors: lambert na. PLoS One. 2021 Apr 22;16(4):e0247743. doi: 10.1371/journal.pone.0247743. eCollection 2021. PLoS One. 2021. PMID: 33886554 Free PMC article.

8

The role of G protein conformation in receptor-G protein selectivity.

Jang W, Lu S, Xu X, Wu G, Lambert NA. Jang W, et al. Among authors: lambert na. Nat Chem Biol. 2023 Jun;19(6):687-694. doi: 10.1038/s41589-022-01231-z. Epub 2023 Jan 16. Nat Chem Biol. 2023. PMID: 36646958 Free PMC article.

9

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

Grätz L, Kowalski-Jahn M, Scharf MM, Kozielewicz P, Jahn M, Bous J, Lambert NA, Gloriam DE, Schulte G. Grätz L, et al. Among authors: lambert na. Nat Commun. 2023 Jul 29;14(1):4573. doi: 10.1038/s41467-023-40213-0. Nat Commun. 2023. PMID: 37516754 Free PMC article.

10

Visualization of endogenous G proteins on endosomes and other organelles.

Jang W, Senarath K, Feinberg G, Lu S, Lambert NA. Jang W, et al. Among authors: lambert na. bioRxiv [Preprint]. 2024 Jul 29:2024.03.05.583500. doi: 10.1101/2024.03.05.583500. bioRxiv. 2024. Update in: Elife. 2024 Nov 08;13:RP97033. doi: 10.7554/eLife.97033 PMID: 38496652 Free PMC article. Updated. Preprint.

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