Davies GJ - Search Results

1

A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase.

Alteen MG, Gros C, Meek RW, Cardoso DA, Busmann JA, Sangouard G, Deen MC, Tan HY, Shen DL, Russell CC, Davies GJ, Robinson PJ, McCluskey A, Vocadlo DJ. Alteen MG, et al. Among authors: davies gj. Angew Chem Int Ed Engl. 2020 Jun 8;59(24):9601-9609. doi: 10.1002/anie.202000621. Epub 2020 Apr 2. Angew Chem Int Ed Engl. 2020. PMID: 32092778

2

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate.

Vocadlo DJ, Davies GJ, Laine R, Withers SG. Vocadlo DJ, et al. Among authors: davies gj. Nature. 2001 Aug 23;412(6849):835-8. doi: 10.1038/35090602. Nature. 2001. PMID: 11518970 Free article.

3

Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state.

Ducros VM, Zechel DL, Murshudov GN, Gilbert HJ, Szabó L, Stoll D, Withers SG, Davies GJ. Ducros VM, et al. Among authors: davies gj. Angew Chem Int Ed Engl. 2002 Aug 2;41(15):2824-7. doi: 10.1002/1521-3773(20020802)41:15<2824::AID-ANIE2824>3.0.CO;2-G. Angew Chem Int Ed Engl. 2002. PMID: 12203498 No abstract available.

4

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.

Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ. Dennis RJ, et al. Among authors: davies gj. Nat Struct Mol Biol. 2006 Apr;13(4):365-71. doi: 10.1038/nsmb1079. Epub 2006 Mar 26. Nat Struct Mol Biol. 2006. PMID: 16565725

5

Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase.

Sheldon WL, Macauley MS, Taylor EJ, Robinson CE, Charnock SJ, Davies GJ, Vocadlo DJ, Black GW. Sheldon WL, et al. Among authors: davies gj. Biochem J. 2006 Oct 15;399(2):241-7. doi: 10.1042/BJ20060307. Biochem J. 2006. PMID: 16822234 Free PMC article.

6

Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases.

Money VA, Smith NL, Scaffidi A, Stick RV, Gilbert HJ, Davies GJ. Money VA, et al. Among authors: davies gj. Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5136-40. doi: 10.1002/anie.200600802. Angew Chem Int Ed Engl. 2006. PMID: 16823793 No abstract available.

7

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Whitworth GE, et al. Among authors: davies gj. J Am Chem Soc. 2007 Jan 24;129(3):635-44. doi: 10.1021/ja065697o. J Am Chem Soc. 2007. PMID: 17227027

8

Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors.

Gibson RP, Gloster TM, Roberts S, Warren RA, Storch de Gracia I, García A, Chiara JL, Davies GJ. Gibson RP, et al. Among authors: davies gj. Angew Chem Int Ed Engl. 2007;46(22):4115-9. doi: 10.1002/anie.200604825. Angew Chem Int Ed Engl. 2007. PMID: 17455176 No abstract available.

9

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases.

Scaffidi A, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Vocadlo DJ, Stick RV. Scaffidi A, et al. Among authors: davies gj. Org Biomol Chem. 2007 Sep 21;5(18):3013-9. doi: 10.1039/b709681j. Epub 2007 Aug 15. Org Biomol Chem. 2007. PMID: 17728868

10

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.

Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ. Martinez-Fleites C, et al. Among authors: davies gj. Nat Struct Mol Biol. 2008 Jul;15(7):764-5. doi: 10.1038/nsmb.1443. Epub 2008 Jun 8. Nat Struct Mol Biol. 2008. PMID: 18536723

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