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TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex.
Coles CH, Mulvaney RM, Malla S, Walker A, Smith KJ, Lloyd A, Lowe KL, McCully ML, Martinez Hague R, Aleksic M, Harper J, Paston SJ, Donnellan Z, Chester F, Wiederhold K, Robinson RA, Knox A, Stacey AR, Dukes J, Baston E, Griffin S, Jakobsen BK, Vuidepot A, Harper S. Coles CH, et al. Among authors: harper j, harper s. J Immunol. 2020 Apr 1;204(7):1943-1953. doi: 10.4049/jimmunol.1900915. Epub 2020 Feb 26. J Immunol. 2020. PMID: 32102902 Free PMC article.
Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
Holland CJ, Crean RM, Pentier JM, de Wet B, Lloyd A, Srikannathasan V, Lissin N, Lloyd KA, Blicher TH, Conroy PJ, Hock M, Pengelly RJ, Spinner TE, Cameron B, Potter EA, Jeyanthan A, Molloy PE, Sami M, Aleksic M, Liddy N, Robinson RA, Harper S, Lepore M, Pudney CR, van der Kamp MW, Rizkallah PJ, Jakobsen BK, Vuidepot A, Cole DK. Holland CJ, et al. Among authors: harper s. J Clin Invest. 2020 May 1;130(5):2673-2688. doi: 10.1172/JCI130562. J Clin Invest. 2020. PMID: 32310221 Free PMC article.
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen.
Poole A, Karuppiah V, Hartt A, Haidar JN, Moureau S, Dobrzycki T, Hayes C, Rowley C, Dias J, Harper S, Barnbrook K, Hock M, Coles C, Yang W, Aleksic M, Lin AB, Robinson R, Dukes JD, Liddy N, Van der Kamp M, Plowman GD, Vuidepot A, Cole DK, Whale AD, Chillakuri C. Poole A, et al. Among authors: harper s. Nat Commun. 2022 Sep 10;13(1):5333. doi: 10.1038/s41467-022-32811-1. Nat Commun. 2022. PMID: 36088370 Free PMC article.
Tuning the potency and selectivity of ImmTAC molecules by affinity modulation.
Robertson IB, Mulvaney R, Dieckmann N, Vantellini A, Canestraro M, Amicarella F, O'Dwyer R, Cole DK, Harper S, Dushek O, Kirk P. Robertson IB, et al. Among authors: harper s. Clin Exp Immunol. 2024 Feb 7;215(2):105-119. doi: 10.1093/cei/uxad120. Clin Exp Immunol. 2024. PMID: 37930865 Free PMC article.
Broadening alloselectivity of T cell receptors by structure guided engineering.
Karuppiah V, Sangani D, Whaley L, Pengelly R, Uluocak P, Carreira RJ, Hock M, Cristina PD, Bartasun P, Dobrinic P, Smith N, Barnbrook K, Robinson RA, Harper S. Karuppiah V, et al. Among authors: harper s. Sci Rep. 2024 Nov 6;14(1):26851. doi: 10.1038/s41598-024-75140-7. Sci Rep. 2024. PMID: 39500929 Free PMC article.
Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy.
Crean RM, MacLachlan BJ, Madura F, Whalley T, Rizkallah PJ, Holland CJ, McMurran C, Harper S, Godkin A, Sewell AK, Pudney CR, van der Kamp MW, Cole DK. Crean RM, et al. Among authors: harper s. Mol Ther Oncolytics. 2020 Jul 31;18:443-456. doi: 10.1016/j.omto.2020.07.008. eCollection 2020 Sep 25. Mol Ther Oncolytics. 2020. PMID: 32913893 Free PMC article.
High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer-testis antigen PRAME.
Ribeiro AR, Britton-Rivet C, Collins L, Carreira RJ, Moureau S, Benlahrech A, Stanhope S, Harper S, Liddy N, Mahon TM, Petrovic K, Fife M, Depoil D, Addis P, Bedke N, Bouard L, O'Dwyer R, Gascoyne D, Ranade K. Ribeiro AR, et al. Among authors: harper s. Immunother Adv. 2024 Nov 2;4(1):ltae008. doi: 10.1093/immadv/ltae008. eCollection 2024. Immunother Adv. 2024. PMID: 39659431 Free PMC article.
Self-efficacy Through Digital Care Plan Participation.
Smith JM, Christopherson LA, Harper SB, Harmsen WS. Smith JM, et al. Among authors: harper sb. Comput Inform Nurs. 2024 Nov 20. doi: 10.1097/CIN.0000000000001220. Online ahead of print. Comput Inform Nurs. 2024. PMID: 39774180
1,687 results