Leclercq K - Search Results

1

Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome.

Auvin S, Dozières-Puyravel B, Avbersek A, Sciberras D, Collier J, Leclercq K, Mares P, Kaminski RM, Muglia P. Auvin S, et al. Among authors: leclercq k. Ann Clin Transl Neurol. 2020 Mar;7(3):343-352. doi: 10.1002/acn3.50998. Epub 2020 Feb 27. Ann Clin Transl Neurol. 2020. PMID: 32106360 Free PMC article. Clinical Trial.

2

SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.

Kaminski RM, Matagne A, Leclercq K, Gillard M, Michel P, Kenda B, Talaga P, Klitgaard H. Kaminski RM, et al. Among authors: leclercq k. Neuropharmacology. 2008 Mar;54(4):715-20. doi: 10.1016/j.neuropharm.2007.11.021. Epub 2007 Dec 8. Neuropharmacology. 2008. PMID: 18207204

3

Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.

Kaminski RM, Gillard M, Leclercq K, Hanon E, Lorent G, Dassesse D, Matagne A, Klitgaard H. Kaminski RM, et al. Among authors: leclercq k. Epilepsia. 2009 Jul;50(7):1729-40. doi: 10.1111/j.1528-1167.2009.02089.x. Epub 2009 Apr 19. Epilepsia. 2009. PMID: 19486357 Free article.

4

11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice.

Kaminski RM, Fu Z, Venkatesan K, Mazzuferi M, Leclercq K, Seutin V, Vicini S. Kaminski RM, et al. Among authors: leclercq k. Neuropharmacology. 2011 Jun;60(7-8):1098-108. doi: 10.1016/j.neuropharm.2010.09.021. Epub 2010 Sep 29. Neuropharmacology. 2011. PMID: 20883706 Free PMC article.

5

Electrical, molecular and behavioral effects of interictal spiking in the rat.

Barkmeier DT, Senador D, Leclercq K, Pai D, Hua J, Boutros NN, Kaminski RM, Loeb JA. Barkmeier DT, et al. Among authors: leclercq k. Neurobiol Dis. 2012 Jul;47(1):92-101. doi: 10.1016/j.nbd.2012.03.026. Epub 2012 Mar 26. Neurobiol Dis. 2012. PMID: 22472188 Free PMC article.

6

Genetic background of mice strongly influences treatment resistance in the 6 Hz seizure model.

Leclercq K, Kaminski RM. Leclercq K, et al. Epilepsia. 2015 Feb;56(2):310-8. doi: 10.1111/epi.12893. Epub 2014 Dec 19. Epilepsia. 2015. PMID: 25524462 Free article.

7

Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.

Leclercq K, Afrikanova T, Langlois M, De Prins A, Buenafe OE, Rospo CC, Van Eeckhaut A, de Witte PA, Crawford AD, Smolders I, Esguerra CV, Kaminski RM. Leclercq K, et al. Epilepsy Behav. 2015 Apr;45:53-63. doi: 10.1016/j.yebeh.2015.03.019. Epub 2015 Apr 3. Epilepsy Behav. 2015. PMID: 25845493 Free article.

8

Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.

Leclercq K, Kaminski RM. Leclercq K, et al. Epilepsy Behav. 2015 Aug;49:55-60. doi: 10.1016/j.yebeh.2015.06.011. Epub 2015 Jun 27. Epilepsy Behav. 2015. PMID: 26123104

9

Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment.

Klitgaard H, Matagne A, Nicolas JM, Gillard M, Lamberty Y, De Ryck M, Kaminski RM, Leclercq K, Niespodziany I, Wolff C, Wood M, Hannestad J, Kervyn S, Kenda B. Klitgaard H, et al. Among authors: leclercq k. Epilepsia. 2016 Apr;57(4):538-48. doi: 10.1111/epi.13340. Epub 2016 Feb 26. Epilepsia. 2016. PMID: 26920914 Free article. Review.

10

Resveratrol lacks protective activity against acute seizures in mouse models.

Tomaciello F, Leclercq K, Kaminski RM. Tomaciello F, et al. Among authors: leclercq k. Neurosci Lett. 2016 Oct 6;632:199-203. doi: 10.1016/j.neulet.2016.09.002. Epub 2016 Sep 4. Neurosci Lett. 2016. PMID: 27600732

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