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A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.
Aslami H, Beurskens CJ, de Beer FM, Kuipers MT, Roelofs JJ, Hegeman MA, Van der Sluijs KF, Schultz MJ, Juffermans NP. Aslami H, et al. Among authors: hegeman ma. Cytokine. 2013 Feb;61(2):614-21. doi: 10.1016/j.cyto.2012.11.018. Epub 2012 Dec 23. Cytokine. 2013. PMID: 23267760
TLR2 deficiency aggravates lung injury caused by mechanical ventilation.
Kuipers MT, Jongsma G, Hegeman MA, Tuip-de Boer AM, Wolthuis EK, Choi G, Bresser P, van der Poll T, Schultz MJ, Wieland CW. Kuipers MT, et al. Among authors: hegeman ma. Shock. 2014 Jul;42(1):60-4. doi: 10.1097/SHK.0000000000000172. Shock. 2014. PMID: 24667617 Clinical Trial.
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