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Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma.
Rad Pour S, Morikawa H, Kiani NA, Yang M, Azimi A, Shafi G, Shang M, Baumgartner R, Ketelhuth DFJ, Kamleh MA, Wheelock CE, Lundqvist A, Hansson J, Tegnér J. Rad Pour S, et al. Among authors: hansson j. Sci Rep. 2019 Aug 21;9(1):12150. doi: 10.1038/s41598-019-48635-x. Sci Rep. 2019. PMID: 31434983 Free PMC article.
Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells.
Azimi A, Tuominen R, Costa Svedman F, Caramuta S, Pernemalm M, Frostvik Stolt M, Kanter L, Kharaziha P, Lehtiö J, Hertzman Johansson C, Höiom V, Hansson J, Egyhazi Brage S. Azimi A, et al. Among authors: hansson j. Cell Death Dis. 2017 Aug 31;8(8):e3029. doi: 10.1038/cddis.2017.406. Cell Death Dis. 2017. PMID: 29048432 Free PMC article.
475 results