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Type II Alexander disease caused by splicing errors and aberrant overexpression of an uncharacterized GFAP isoform.
Helman G, Takanohashi A, Hagemann TL, Perng MD, Walkiewicz M, Woidill S, Sase S, Cross Z, Du Y, Zhao L, Waldman A, Haake BC, Fatemi A, Brenner M, Sherbini O, Messing A, Vanderver A, Simons C. Helman G, et al. Among authors: messing a. Hum Mutat. 2020 Jun;41(6):1131-1137. doi: 10.1002/humu.24008. Epub 2020 Mar 11. Hum Mutat. 2020. PMID: 32126152 Free PMC article.
GFAP Transgenic Mice.
Brenner M, Messing A. Brenner M, et al. Among authors: messing a. Methods. 1996 Dec;10(3):351-64. doi: 10.1006/meth.1996.0113. Methods. 1996. PMID: 8954847
Astrocytes cultured from transgenic mice carrying the added human glial fibrillary acidic protein gene contain Rosenthal fibers.
Eng LF, Lee YL, Kwan H, Brenner M, Messing A. Eng LF, et al. Among authors: messing a. J Neurosci Res. 1998 Aug 1;53(3):353-60. doi: 10.1002/(SICI)1097-4547(19980801)53:3<353::AID-JNR9>3.0.CO;2-9. J Neurosci Res. 1998. PMID: 9698163
Astrocyte cultures prepared from a low overexpressor (Tg73.2) exhibited abnormal cytoplasmic inclusions identical to those seen in vivo in the high overexpressors. ...Ultrastructurally, the Tg73.2 astrocytes contain osmophilic deposits on a bed of intermediate filam …
Astrocyte cultures prepared from a low overexpressor (Tg73.2) exhibited abnormal cytoplasmic inclusions identical to those seen in vi …
177 results