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Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A. Porcheri C, et al. Among authors: wang x. EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9. EMBO J. 2020. PMID: 32149421 Free PMC article.
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E. Hérault A, et al. Among authors: wang x. Nature. 2017 Apr 6;544(7648):53-58. doi: 10.1038/nature21693. Epub 2017 Mar 29. Nature. 2017. PMID: 28355185 Free PMC article.
Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq.
Lescroart F, Wang X, Lin X, Swedlund B, Gargouri S, Sànchez-Dànes A, Moignard V, Dubois C, Paulissen C, Kinston S, Göttgens B, Blanpain C. Lescroart F, et al. Among authors: wang x. Science. 2018 Mar 9;359(6380):1177-1181. doi: 10.1126/science.aao4174. Epub 2018 Jan 25. Science. 2018. PMID: 29371425 Free PMC article.
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.
Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambilet D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P. Bueno C, et al. Among authors: wang x. Haematologica. 2019 Jun;104(6):1189-1201. doi: 10.3324/haematol.2018.202044. Epub 2019 Jan 24. Haematologica. 2019. PMID: 30679325 Free PMC article.
GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm.
Castaño J, Aranda S, Bueno C, Calero-Nieto FJ, Mejia-Ramirez E, Mosquera JL, Blanco E, Wang X, Prieto C, Zabaleta L, Mereu E, Rovira M, Jiménez-Delgado S, Matson DR, Heyn H, Bresnick EH, Göttgens B, Di Croce L, Menendez P, Raya A, Giorgetti A. Castaño J, et al. Among authors: wang x. Stem Cell Reports. 2019 Sep 10;13(3):515-529. doi: 10.1016/j.stemcr.2019.07.009. Epub 2019 Aug 8. Stem Cell Reports. 2019. PMID: 31402335 Free PMC article.
STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion.
Li J, Williams MJ, Park HJ, Bastos HP, Wang X, Prins D, Wilson NK, Johnson C, Sham K, Wantoch M, Watcham S, Kinston SJ, Pask DC, Hamilton TL, Sneade R, Waller AK, Ghevaert C, Vassiliou GS, Laurenti E, Kent DG, Göttgens B, Green AR. Li J, et al. Among authors: wang x. Blood. 2022 Oct 6;140(14):1592-1606. doi: 10.1182/blood.2021014009. Blood. 2022. PMID: 35767701 Free PMC article.
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