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Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions.
Umehara K, Huth F, Jin Y, Schiller H, Aslanis V, Heimbach T, He H. Umehara K, et al. Among authors: he h. Drug Metab Pers Ther. 2019 May 30;34(2):/j/dmdi.2019.34.issue-2/dmpt-2018-0042/dmpt-2018-0042.xml. doi: 10.1515/dmpt-2018-0042. Drug Metab Pers Ther. 2019. PMID: 31145690
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