Du Q - Search Results

1

Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists.

Xu X, Du Q, Meng Y, Li Z, Wu H, Li Y, Zhao Z, Ge R, Lu X, Xue S, Chen X, Yang Y, Wang J, Bian J. Xu X, et al. Among authors: du q. Eur J Med Chem. 2020 Apr 15;192:112196. doi: 10.1016/j.ejmech.2020.112196. Epub 2020 Mar 5. Eur J Med Chem. 2020. PMID: 32169785

2

Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-β-catenin axis.

Du Q, Wang Y, Liu C, Wang H, Fan H, Li Y, Wang J, Zhang X, Lu J, Ji H, Hu R. Du Q, et al. Oncotarget. 2016 Apr 5;7(14):17870-84. doi: 10.18632/oncotarget.7554. Oncotarget. 2016. PMID: 26910375 Free PMC article.

3

Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.

Du Q, Feng X, Wang Y, Xu X, Zhang Y, Qu X, Li Z, Bian J. Du Q, et al. Eur J Med Chem. 2019 Nov 15;182:111629. doi: 10.1016/j.ejmech.2019.111629. Epub 2019 Aug 18. Eur J Med Chem. 2019. PMID: 31445231

4

The Potential Clinical Value of Curcumin and its Derivatives in Colorectal Cancer.

Yao Z, Le TH, Du Q, Mu H, Liu C, Zhu Y. Yao Z, et al. Among authors: du q. Anticancer Agents Med Chem. 2021;21(13):1626-1637. doi: 10.2174/1871520620999201113095821. Anticancer Agents Med Chem. 2021. PMID: 33191888 Review.

5

Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation.

Xu X, Zhang D, Zhao T, Wang M, Li Y, Du Q, Kou J, Li Z, Bian J. Xu X, et al. Among authors: du q. Eur J Med Chem. 2022 Apr 5;233:114228. doi: 10.1016/j.ejmech.2022.114228. Epub 2022 Feb 24. Eur J Med Chem. 2022. PMID: 35245830

6

Design, synthesis and biological evaluation of fluorinated selective estrogen receptor degraders (FSERDs) --- A promising strategy for advanced ER positive breast cancer.

Lu Y, Liu C, Wang X, Liu L, Zhao Z, Liang Z, Liu Y, Wen Z, Du Q, Liu W. Lu Y, et al. Among authors: du q. Eur J Med Chem. 2023 May 5;253:115324. doi: 10.1016/j.ejmech.2023.115324. Epub 2023 Mar 30. Eur J Med Chem. 2023. PMID: 37019030

7

Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer.

Chang X, Zhang D, Qu F, Xie Y, Chen T, Zhang Y, Du Q, Bian J, Li Z, Wang J, Xu X. Chang X, et al. Among authors: du q. Eur J Med Chem. 2023 Sep 5;257:115490. doi: 10.1016/j.ejmech.2023.115490. Epub 2023 May 18. Eur J Med Chem. 2023. PMID: 37209451

8

The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364.

Tian Y, Liu K, Wu D, Wu L, Xu Q, Wei W, Li Z, Du Q, Bian J. Tian Y, et al. Among authors: du q. Eur J Med Chem. 2024 Mar 15;268:116275. doi: 10.1016/j.ejmech.2024.116275. Epub 2024 Feb 24. Eur J Med Chem. 2024. PMID: 38452725

9

Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.

Lu Y, Liang Z, Liu L, Zhou Y, Liu C, Zhao Z, Zheng T, Du Q, Liu W. Lu Y, et al. Among authors: du q. Eur J Med Chem. 2024 Sep 5;275:116534. doi: 10.1016/j.ejmech.2024.116534. Epub 2024 May 27. Eur J Med Chem. 2024. PMID: 38870830

10

Drug discovery of N-methyl-pyrazole derivatives as potent selective estrogen receptor degrader (SERD) for the treatment of breast cancer.

Dai R, Bao X, Liu C, Yin X, Zhu Z, Zheng Z, Wang B, Yang K, Wen H, Li W, Zhu H, Du Q, Liu J. Dai R, et al. Among authors: du q. Eur J Med Chem. 2024 Dec 5;279:116894. doi: 10.1016/j.ejmech.2024.116894. Epub 2024 Sep 23. Eur J Med Chem. 2024. PMID: 39357315

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