Searle MS - Search Results

1

G-quadruplex ligands mediate downregulation of DUX4 expression.

Ciszewski L, Lu-Nguyen N, Slater A, Brennan A, Williams HEL, Dickson G, Searle MS, Popplewell L. Ciszewski L, et al. Among authors: searle ms. Nucleic Acids Res. 2020 May 7;48(8):4179-4194. doi: 10.1093/nar/gkaa146. Nucleic Acids Res. 2020. PMID: 32182342 Free PMC article.

2

DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA-DnaD interaction.

Martin E, Williams HEL, Pitoulias M, Stevens D, Winterhalter C, Craggs TD, Murray H, Searle MS, Soultanas P. Martin E, et al. Among authors: searle ms. Nucleic Acids Res. 2019 Feb 28;47(4):2101-2112. doi: 10.1093/nar/gky1220. Nucleic Acids Res. 2019. PMID: 30534966 Free PMC article.

3

Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad.

Searle MS, Williams HE, Gallagher CT, Grant RJ, Stevens MF. Searle MS, et al. Org Biomol Chem. 2004 Mar 21;2(6):810-2. doi: 10.1039/b314559j. Epub 2004 Feb 18. Org Biomol Chem. 2004. PMID: 15007406

4

Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop.

Balkwill GD, Garner TP, Williams HE, Searle MS. Balkwill GD, et al. Among authors: searle ms. J Mol Biol. 2009 Feb 6;385(5):1600-15. doi: 10.1016/j.jmb.2008.11.050. Epub 2008 Dec 3. J Mol Biol. 2009. PMID: 19070621

5

Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

Garner TP, Williams HE, Gluszyk KI, Roe S, Oldham NJ, Stevens MF, Moses JE, Searle MS. Garner TP, et al. Among authors: searle ms. Org Biomol Chem. 2009 Oct 21;7(20):4194-200. doi: 10.1039/b910505k. Epub 2009 Aug 14. Org Biomol Chem. 2009. PMID: 19795057

6

Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution.

Williams HE, Searle MS. Williams HE, et al. Among authors: searle ms. J Mol Biol. 1999 Jul 16;290(3):699-716. doi: 10.1006/jmbi.1999.2903. J Mol Biol. 1999. PMID: 10395824

7

Drug recognition of a DNA single strand break: nogalamycin intercalation between coaxially stacked hairpins.

Williams HE, Colgrave ML, Searle MS. Williams HE, et al. Among authors: searle ms. Eur J Biochem. 2002 Mar;269(6):1726-33. doi: 10.1046/j.1432-1327.2002.02819.x. Eur J Biochem. 2002. PMID: 11895443 Free article.

8

Structure of a drug-induced DNA T-bulge: implications for DNA frameshift mutations.

Colgrave ML, Williams HE, Searle MS. Colgrave ML, et al. Among authors: searle ms. Angew Chem Int Ed Engl. 2002 Dec 16;41(24):4754-6. doi: 10.1002/anie.200290039. Angew Chem Int Ed Engl. 2002. PMID: 12481349 No abstract available.

9

Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.

Linder J, Garner TP, Williams HE, Searle MS, Moody CJ. Linder J, et al. Among authors: searle ms. J Am Chem Soc. 2011 Feb 2;133(4):1044-51. doi: 10.1021/ja109158k. Epub 2010 Dec 16. J Am Chem Soc. 2011. PMID: 21162526

10

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.

Brennan A, Layfield R, Long J, Williams HEL, Oldham NJ, Scott D, Searle MS. Brennan A, et al. Among authors: searle ms. J Biol Chem. 2022 Feb;298(2):101514. doi: 10.1016/j.jbc.2021.101514. Epub 2021 Dec 18. J Biol Chem. 2022. PMID: 34929165 Free PMC article.

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