Dai H - Search Results

1

Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs.

Anderson NA, Cryan J, Ahmed A, Dai H, McGonagle GA, Rozier C, Benowitz AB. Anderson NA, et al. Among authors: dai h. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. doi: 10.1016/j.bmcl.2020.127106. Epub 2020 Mar 10. Bioorg Med Chem Lett. 2020. PMID: 32184044

2

Structural Insights into PROTAC-Mediated Degradation of Bcl-xL.

Chung CW, Dai H, Fernandez E, Tinworth CP, Churcher I, Cryan J, Denyer J, Harling JD, Konopacka A, Queisser MA, Tame CJ, Watt G, Jiang F, Qian D, Benowitz AB. Chung CW, et al. Among authors: dai h. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323. doi: 10.1021/acschembio.0c00266. Epub 2020 Aug 13. ACS Chem Biol. 2020. PMID: 32697072

3

Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs.

Law RP, Nunes J, Chung CW, Bantscheff M, Buda K, Dai H, Evans JP, Flinders A, Klimaszewska D, Lewis AJ, Muelbaier M, Scott-Stevens P, Stacey P, Tame CJ, Watt GF, Zinn N, Queisser MA, Harling JD, Benowitz AB. Law RP, et al. Among authors: dai h. Angew Chem Int Ed Engl. 2021 Oct 18;60(43):23327-23334. doi: 10.1002/anie.202109237. Epub 2021 Sep 17. Angew Chem Int Ed Engl. 2021. PMID: 34416073

4

PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding.

Tinworth CP, Lithgow H, Dittus L, Bassi ZI, Hughes SE, Muelbaier M, Dai H, Smith IED, Kerr WJ, Burley GA, Bantscheff M, Harling JD. Tinworth CP, et al. Among authors: dai h. ACS Chem Biol. 2019 Mar 15;14(3):342-347. doi: 10.1021/acschembio.8b01094. Epub 2019 Feb 27. ACS Chem Biol. 2019. PMID: 30807093 Free article.

5

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.

Disch JS, Evindar G, Chiu CH, Blum CA, Dai H, Jin L, Schuman E, Lind KE, Belyanskaya SL, Deng J, Coppo F, Aquilani L, Graybill TL, Cuozzo JW, Lavu S, Mao C, Vlasuk GP, Perni RB. Disch JS, et al. Among authors: dai h. J Med Chem. 2013 May 9;56(9):3666-79. doi: 10.1021/jm400204k. Epub 2013 Apr 29. J Med Chem. 2013. PMID: 23570514

6

Key Considerations in Targeted Protein Degradation Drug Discovery and Development.

Qin L, Dai H, Wang J. Qin L, et al. Among authors: dai h. Front Chem. 2022 Aug 1;10:934337. doi: 10.3389/fchem.2022.934337. eCollection 2022. Front Chem. 2022. PMID: 35978859 Free PMC article. Review.

7

Synthesis and Assay of SIRT1-Activating Compounds.

Dai H, Ellis JL, Sinclair DA, Hubbard BP. Dai H, et al. Methods Enzymol. 2016;574:213-244. doi: 10.1016/bs.mie.2016.01.012. Epub 2016 Feb 9. Methods Enzymol. 2016. PMID: 27423864 Free PMC article.

8

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Dai H, Sinclair DA, Ellis JL, Steegborn C. Dai H, et al. Pharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22. Pharmacol Ther. 2018. PMID: 29577959 Free PMC article. Review.

9

Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5.

Szczepankiewicz BG, Dai H, Koppetsch KJ, Qian D, Jiang F, Mao C, Perni RB. Szczepankiewicz BG, et al. Among authors: dai h. J Org Chem. 2012 Sep 7;77(17):7319-29. doi: 10.1021/jo301067e. Epub 2012 Aug 17. J Org Chem. 2012. PMID: 22849721

10

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL. Dai H, et al. J Biol Chem. 2010 Oct 22;285(43):32695-32703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11. J Biol Chem. 2010. PMID: 20702418 Free PMC article.

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