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Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein.
Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B. Boateng SY, et al. Among authors: de tombe pp. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H259-69. doi: 10.1152/ajpheart.00766.2006. Epub 2006 Sep 8. Am J Physiol Heart Circ Physiol. 2007. PMID: 16963613 Free article.
Myofilament length dependent activation.
de Tombe PP, Mateja RD, Tachampa K, Ait Mou Y, Farman GP, Irving TC. de Tombe PP, et al. J Mol Cell Cardiol. 2010 May;48(5):851-8. doi: 10.1016/j.yjmcc.2009.12.017. Epub 2010 Jan 4. J Mol Cell Cardiol. 2010. PMID: 20053351 Free PMC article. Review.
Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.
Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S. Witayavanitkul N, et al. Among authors: de tombe pp. J Biol Chem. 2014 Mar 28;289(13):8818-27. doi: 10.1074/jbc.M113.541128. Epub 2014 Feb 7. J Biol Chem. 2014. PMID: 24509847 Free PMC article.
Cardiac muscle mechanics: Sarcomere length matters.
de Tombe PP, ter Keurs HE. de Tombe PP, et al. J Mol Cell Cardiol. 2016 Feb;91:148-50. doi: 10.1016/j.yjmcc.2015.12.006. Epub 2015 Dec 8. J Mol Cell Cardiol. 2016. PMID: 26678623 Free PMC article. No abstract available.
Pacemaker-induced transient asynchrony suppresses heart failure progression.
Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA. Kirk JA, et al. Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899. Sci Transl Med. 2015. PMID: 26702095 Free PMC article.
189 results