Cheng AC - Search Results

1

Experimental Error, Kurtosis, Activity Cliffs, and Methodology: What Limits the Predictivity of Quantitative Structure-Activity Relationship Models?

Sheridan RP, Karnachi P, Tudor M, Xu Y, Liaw A, Shah F, Cheng AC, Joshi E, Glick M, Alvarez J. Sheridan RP, et al. Among authors: cheng ac. J Chem Inf Model. 2020 Apr 27;60(4):1969-1982. doi: 10.1021/acs.jcim.9b01067. Epub 2020 Apr 15. J Chem Inf Model. 2020. PMID: 32207612

2

Improvement in ADMET Prediction with Multitask Deep Featurization.

Feinberg EN, Joshi E, Pande VS, Cheng AC. Feinberg EN, et al. Among authors: cheng ac. J Med Chem. 2020 Aug 27;63(16):8835-8848. doi: 10.1021/acs.jmedchem.9b02187. Epub 2020 May 12. J Med Chem. 2020. PMID: 32286824

3

Deep learning approaches in predicting ADMET properties.

Cáceres EL, Tudor M, Cheng AC. Cáceres EL, et al. Among authors: cheng ac. Future Med Chem. 2020 Nov;12(22):1995-1999. doi: 10.4155/fmc-2020-0259. Epub 2020 Oct 30. Future Med Chem. 2020. PMID: 33124448 Review. No abstract available.

4

Exploring Deep Learning of Quantum Chemical Properties for Absorption, Distribution, Metabolism, and Excretion Predictions.

Lim MA, Yang S, Mai H, Cheng AC. Lim MA, et al. Among authors: cheng ac. J Chem Inf Model. 2022 Dec 26;62(24):6336-6341. doi: 10.1021/acs.jcim.2c00245. Epub 2022 Jun 27. J Chem Inf Model. 2022. PMID: 35758421 Review.

5

Denoising Drug Discovery Data for Improved Absorption, Distribution, Metabolism, Excretion, and Toxicity Property Prediction.

Adrian M, Chung Y, Cheng AC. Adrian M, et al. Among authors: cheng ac. J Chem Inf Model. 2024 Aug 26;64(16):6324-6337. doi: 10.1021/acs.jcim.4c00639. Epub 2024 Aug 7. J Chem Inf Model. 2024. PMID: 39108185

6

Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity.

Pande K, Hollingsworth SA, Sam M, Gao Q, Singh S, Saha A, Vroom K, Ma XS, Brazell T, Gorman D, Chen SJ, Raoufi F, Bailly M, Grandy D, Sathiyamoorthy K, Zhang L, Thompson R, Cheng AC, Fayadat-Dilman L, Geierstanger BH, Kingsley LJ. Pande K, et al. Among authors: cheng ac. Front Immunol. 2022 May 4;13:864775. doi: 10.3389/fimmu.2022.864775. eCollection 2022. Front Immunol. 2022. PMID: 35603164 Free PMC article.

7

A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties.

Waight AB, Prihoda D, Shrestha R, Metcalf K, Bailly M, Ancona M, Widatalla T, Rollins Z, Cheng AC, Bitton DA, Fayadat-Dilman L. Waight AB, et al. Among authors: cheng ac. MAbs. 2023 Jan-Dec;15(1):2248671. doi: 10.1080/19420862.2023.2248671. MAbs. 2023. PMID: 37610144 Free PMC article.

8

AbMelt: Learning antibody thermostability from molecular dynamics.

Rollins ZA, Widatalla T, Cheng AC, Metwally E. Rollins ZA, et al. Among authors: cheng ac. Biophys J. 2024 Sep 3;123(17):2921-2933. doi: 10.1016/j.bpj.2024.06.003. Epub 2024 Jun 7. Biophys J. 2024. PMID: 38851888

9

Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α.

Mak VW, Patel AM, Yen R, Hanisak J, Lim YH, Bao J, Zheng R, Seganish WM, Yu Y, Healy DR, Ogawa A, Ren Z, Soriano A, Ermakov GP, Beaumont M, Metwally E, Cheng AC, Verras A, Fischmann T, Zebisch M, Silvestre HL, McEwan PA, Barker J, Rearden P, Greshock TJ. Mak VW, et al. Among authors: cheng ac. J Med Chem. 2022 Aug 11;65(15):10318-10340. doi: 10.1021/acs.jmedchem.1c02109. Epub 2022 Jul 25. J Med Chem. 2022. PMID: 35878399

10

Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads.

Patel AM, Willingham A, Cheng AC, Tomazela D, Bowman E, Kofman E, Zhang F, Bao J, Sanzone JR, Choy JW, Flygare JA, Han JH, Pradhan K, Kieffer M, Chernyak N, Akbari P, Liu P, Mehmood R, Naravula S, Hollingsworth SA, Bhagwat B, Lang SB, Seganish WM. Patel AM, et al. Among authors: cheng ac. J Med Chem. 2024 Sep 12;67(17):15756-15779. doi: 10.1021/acs.jmedchem.4c01384. Epub 2024 Aug 22. J Med Chem. 2024. PMID: 39172064

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