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Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa.
Coutry N, Nguyen J, Soualhi S, Gerbe F, Meslier V, Dardalhon V, Almeida M, Quinquis B, Thirion F, Herbert F, Gasmi I, Lamrani A, Giordano A, Cesses P, Garnier L, Thirard S, Greuet D, Cazevieille C, Bernex F, Bressuire C, Winton D, Matsumoto I, Blottière HM, Taylor N, Jay P. Coutry N, et al. Among authors: giordano a. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2219431120. doi: 10.1073/pnas.2219431120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307458 Free PMC article.
Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity.
Ndjim M, Gasmi I, Herbert F, Joséphine C, Bas J, Lamrani A, Coutry N, Henry S, Zimmermann VS, Dardalhon V, Campillo Poveda M, Turtoi E, Thirard S, Forichon L, Giordano A, Ciancia C, Homayed Z, Pannequin J, Britton C, Devaney E, McNeilly TN, Berrard S, Turtoi A, Maizels RM, Gerbe F, Jay P. Ndjim M, et al. Among authors: giordano a. Immunity. 2024 Jun 11;57(6):1260-1273.e7. doi: 10.1016/j.immuni.2024.04.018. Epub 2024 May 13. Immunity. 2024. PMID: 38744292 Free article.
Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death.
Mazzarotti G, Cuomo M, Ragosta MC, Russo A, D'Angelo M, Medugno A, Napolitano GM, Iannuzzi CA, Forte IM, Camerlingo R, Burk S, Errichiello F, Frusciante L, Forino M, Campitiello MR, De Laurentiis M, Giordano A, Alfano L. Mazzarotti G, et al. Among authors: giordano a. Int J Mol Sci. 2024 Dec 16;25(24):13475. doi: 10.3390/ijms252413475. Int J Mol Sci. 2024. PMID: 39769237 Free PMC article.
Ileal Predominance in Crohn's Disease Is Associated With Increased Intestinal Surgery and Biological Therapy Use, With Lower Treatment Persistence.
Giordano A, Pérez-Martínez I, Gisbert JP, Ricart E, Martín-Arranz MD, Mesonero F, De Castro Parga ML, Rivero M, Iglesias E, Fernández-Prada S, Calafat M, Arroyo Villarino MT, Ángel de Jorge Turrión M, Hernandez-Camba A, Lidón RV, Carpio D, Brunet E, Moranta FR, García LA, Cuquerella JT, Bermejo F, Madero L, Esteve M, González-Muñoza C, Martínez-Montiel P, Huguet JM, Pérez Calle JL, Rodríguez-Lago I, Ausín MS, Lorente Poyatos RH, García-Bosch O, Marín GS, Taxonera C, Ponferrada-Diaz Á, Acosta MB, Bujanda L, Serra RB, Ramos L, Vera I, Abizanda ES, Piqueras M, Gómez CS, García-Sepulcre MF, Arregui MV, Murillo NR, LLaó J, Lucendo AJ, Marín-Jiménez I, Camps-Aler B, Villafranca CM, Ceballos D, Ver Y, Fernández-Salazar LI, Alcaín G, Valldosera G, Andrés PR, Martínez-Flores C, Coronel AF, Ginard D, García L, Gómez IB, Argüelles-Arias F, Miyashiro EI, De la Piscina PR, Villalba LH, Notari PA, de Jesús Martínez-Pérez T, Fernández H, Gilabert P, Rosas CM, Nos P, Gil JL, Navas López VM, Muñoz F, Diz-Lois Palomares MT, Lucio AS, Merino O, Nicolás de Prado I, Leal C, Martín de Carpi J, Sánchez LB, Arce NM, Frago S, Mateu BB, Domènech E, Planella EG; ENEIDA project of GETECCU. Giordano A, et al. Am J Gastroenterol. 2025 Jan 1;120(1):194-203. doi: 10.14309/ajg.0000000000003207. Epub 2024 Nov 14. Am J Gastroenterol. 2025. PMID: 39745305
2,841 results