Han XR - Search Results

1

Discovery of Selective Small Molecule Degraders of BRAF-V600E.

Han XR, Chen L, Wei Y, Yu W, Chen Y, Zhang C, Jiao B, Shi T, Sun L, Zhang C, Xu Y, Lee MR, Luo Y, Plewe MB, Wang J. Han XR, et al. J Med Chem. 2020 Apr 23;63(8):4069-4080. doi: 10.1021/acs.jmedchem.9b02083. Epub 2020 Apr 10. J Med Chem. 2020. PMID: 32223235

2

Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).

Zhang C, Han XR, Yang X, Jiang B, Liu J, Xiong Y, Jin J. Zhang C, et al. Among authors: han xr. Eur J Med Chem. 2018 May 10;151:304-314. doi: 10.1016/j.ejmech.2018.03.071. Epub 2018 Mar 27. Eur J Med Chem. 2018. PMID: 29627725 Free PMC article.

3

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.

Cheng M, Yu X, Lu K, Xie L, Wang L, Meng F, Han X, Chen X, Liu J, Xiong Y, Jin J. Cheng M, et al. J Med Chem. 2020 Feb 13;63(3):1216-1232. doi: 10.1021/acs.jmedchem.9b01566. Epub 2020 Jan 14. J Med Chem. 2020. PMID: 31895569 Free PMC article.

4

Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders.

Chen L, Chen Y, Zhang C, Jiao B, Liang S, Tan Q, Chai H, Yu W, Qian Y, Yang H, Yao W, Yu J, Luo Y, Plewe M, Wang J, Han XR, Liu J. Chen L, et al. Among authors: han xr. J Med Chem. 2020 Dec 10;63(23):14562-14575. doi: 10.1021/acs.jmedchem.0c01342. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33058680

5

ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3.

Hu M, Bao R, Lin M, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, Yuan HX. Hu M, et al. Among authors: han xr. Oncogene. 2022 Sep;41(40):4547-4559. doi: 10.1038/s41388-022-02453-0. Epub 2022 Sep 5. Oncogene. 2022. PMID: 36064579

6

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.

Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. Xiong Y, et al. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. J Am Chem Soc. 2022. PMID: 36448571 Free PMC article.

7

A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.

Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. Zha Z, et al. Mol Cell. 2015 Jun 4;58(5):794-803. doi: 10.1016/j.molcel.2015.04.017. Epub 2015 May 14. Mol Cell. 2015. PMID: 25982117 Free PMC article.

8

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.

Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. Zhang T, et al. Elife. 2015 Mar 30;4:e06734. doi: 10.7554/eLife.06734. Elife. 2015. PMID: 25821988 Free PMC article.

9

CRL4^DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development.

Han XR, Sasaki N, Jackson SC, Wang P, Li Z, Smith MD, Xie L, Chen X, Zhang Y, Marzluff WF, Xiong Y. Han XR, et al. Sci Adv. 2020 Dec 18;6(51):eabd6078. doi: 10.1126/sciadv.abd6078. Print 2020 Dec. Sci Adv. 2020. PMID: 33355139 Free PMC article.

10

Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone.

He YN, Han XR, Wang D, Hou JL, Hou XM. He YN, et al. Among authors: han xr. Biochem Biophys Res Commun. 2024 Jun 25;714:149964. doi: 10.1016/j.bbrc.2024.149964. Epub 2024 Apr 22. Biochem Biophys Res Commun. 2024. PMID: 38669753

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