Lee MR - Search Results

1

Discovery of Selective Small Molecule Degraders of BRAF-V600E.

Han XR, Chen L, Wei Y, Yu W, Chen Y, Zhang C, Jiao B, Shi T, Sun L, Zhang C, Xu Y, Lee MR, Luo Y, Plewe MB, Wang J. Han XR, et al. Among authors: lee mr. J Med Chem. 2020 Apr 23;63(8):4069-4080. doi: 10.1021/acs.jmedchem.9b02083. Epub 2020 Apr 10. J Med Chem. 2020. PMID: 32223235

2

Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458).

Liu L, Siegmund A, Xi N, Kaplan-Lefko P, Rex K, Chen A, Lin J, Moriguchi J, Berry L, Huang L, Teffera Y, Yang Y, Zhang Y, Bellon SF, Lee M, Shimanovich R, Bak A, Dominguez C, Norman MH, Harmange JC, Dussault I, Kim TS. Liu L, et al. J Med Chem. 2008 Jul 10;51(13):3688-91. doi: 10.1021/jm800401t. Epub 2008 Jun 14. J Med Chem. 2008. PMID: 18553959

3

Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases.

Chen N, Bürli RW, Neira S, Hungate R, Zhang D, Yu V, Nguyen Y, Tudor Y, Plant M, Flynn S, Meagher KL, Lee MR, Zhang X, Itano A, Schrag M, Xu Y, Ng GY, Hu E. Chen N, et al. Among authors: lee mr. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4137-41. doi: 10.1016/j.bmcl.2008.05.089. Epub 2008 May 28. Bioorg Med Chem Lett. 2008. PMID: 18554909

4

Design, synthesis, and biological evaluation of potent c-Met inhibitors.

D'Angelo ND, Bellon SF, Booker SK, Cheng Y, Coxon A, Dominguez C, Fellows I, Hoffman D, Hungate R, Kaplan-Lefko P, Lee MR, Li C, Liu L, Rainbeau E, Reider PJ, Rex K, Siegmund A, Sun Y, Tasker AS, Xi N, Xu S, Yang Y, Zhang Y, Burgess TL, Dussault I, Kim TS. D'Angelo ND, et al. Among authors: lee mr. J Med Chem. 2008 Sep 25;51(18):5766-79. doi: 10.1021/jm8006189. J Med Chem. 2008. PMID: 18763753

5

Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.

Allen JG, Lee MR, Han CY, Scherrer J, Flynn S, Boucher C, Zhao H, O'Connor AB, Roveto P, Bauer D, Graceffa R, Richards WG, Babij P. Allen JG, et al. Among authors: lee mr. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4924-8. doi: 10.1016/j.bmcl.2009.07.084. Epub 2009 Jul 22. Bioorg Med Chem Lett. 2009. PMID: 19648005

6

Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.

Smith AL, DeMorin FF, Paras NA, Huang Q, Petkus JK, Doherty EM, Nixey T, Kim JL, Whittington DA, Epstein LF, Lee MR, Rose MJ, Babij C, Fernando M, Hess K, Le Q, Beltran P, Carnahan J. Smith AL, et al. Among authors: lee mr. J Med Chem. 2009 Oct 22;52(20):6189-92. doi: 10.1021/jm901081g. J Med Chem. 2009. PMID: 19764794

7

Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.

Pettus LH, Wurz RP, Xu S, Herberich B, Henkle B, Liu Q, McBride HJ, Mu S, Plant MH, Saris CJ, Sherman L, Wong LM, Chmait S, Lee MR, Mohr C, Hsieh F, Tasker AS. Pettus LH, et al. Among authors: lee mr. J Med Chem. 2010 Apr 8;53(7):2973-85. doi: 10.1021/jm100095x. J Med Chem. 2010. PMID: 20218619

8

Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.

Wu B, Wang HL, Pettus L, Wurz RP, Doherty EM, Henkle B, McBride HJ, Saris CJ, Wong LM, Plant MH, Sherman L, Lee MR, Hsieh F, Tasker AS. Wu B, et al. Among authors: lee mr. J Med Chem. 2010 Sep 9;53(17):6398-411. doi: 10.1021/jm100567y. J Med Chem. 2010. PMID: 20712346

9

Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.

Ashton KS, St Jean DJ Jr, Poon SF, Lee MR, Allen JG, Zhang S, Lofgren JA, Zhang X, Fotsch C, Hungate R. Ashton KS, et al. Among authors: lee mr. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6. doi: 10.1016/j.bmcl.2011.07.056. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21824779

10

Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.

Liu L, Norman MH, Lee M, Xi N, Siegmund A, Boezio AA, Booker S, Choquette D, D'Angelo ND, Germain J, Yang K, Yang Y, Zhang Y, Bellon SF, Whittington DA, Harmange JC, Dominguez C, Kim TS, Dussault I. Liu L, et al. J Med Chem. 2012 Mar 8;55(5):1868-97. doi: 10.1021/jm201331s. Epub 2012 Feb 24. J Med Chem. 2012. PMID: 22320327

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