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Methyl 5-[(1H-indol-3-yl)selanyl]-1H-benzoimidazol-2-ylcarbamate (M-24), a novel tubulin inhibitor, causes G2/M arrest and cell apoptosis by disrupting tubulin polymerization in human cervical and breast cancer cells.
Zuo D, Jiang X, Han M, Shen J, Lang B, Guan Q, Bai Z, Han C, Li Z, Zhang W, Wu Y. Zuo D, et al. Among authors: shen j. Toxicol In Vitro. 2017 Aug;42:139-149. doi: 10.1016/j.tiv.2017.04.019. Epub 2017 Apr 13. Toxicol In Vitro. 2017. PMID: 28412508
5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells.
Han M, Shen J, Wang L, Wang Y, Zhai X, Li Y, Liu M, Li Z, Zuo D, Wu Y. Han M, et al. Among authors: shen j. Chem Biol Interact. 2018 Mar 25;284:24-31. doi: 10.1016/j.cbi.2018.02.018. Epub 2018 Feb 16. Chem Biol Interact. 2018. PMID: 29458018
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells.
Wang L, Xu X, Liu T, Wang J, Shen J, Guo M, Wu Y, Zhai X, Zuo D. Wang L, et al. Among authors: shen j. J Pharm Pharmacol. 2020 Oct;72(10):1370-1382. doi: 10.1111/jphp.13315. Epub 2020 Jun 28. J Pharm Pharmacol. 2020. PMID: 32596809
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