Zhai X - Search Results

1

ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.

Gou W, Li Z, Xu X, Shen J, Guo M, Zhou X, Zhang X, Wu Y, Zhai X, Zuo D. Gou W, et al. Among authors: zhai x. Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118712. doi: 10.1016/j.bbamcr.2020.118712. Epub 2020 Mar 26. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 32224191 Free article.

2

Design, synthesis and biological evaluation of novel 4-arylaminopyrimidine derivatives possessing a hydrazone moiety as dual inhibitors of L1196M ALK and ROS1.

Wang Y, Zhang G, Hu G, Bu Y, Lei H, Zuo D, Han M, Zhai X, Gong P. Wang Y, et al. Among authors: zhai x. Eur J Med Chem. 2016 Nov 10;123:80-89. doi: 10.1016/j.ejmech.2016.06.056. Epub 2016 Jul 12. Eur J Med Chem. 2016. PMID: 27474925

3

Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors.

Wang X, Jiang N, Zhao S, Xi S, Wang J, Jing T, Zhang W, Guo M, Gong P, Zhai X. Wang X, et al. Among authors: zhai x. Bioorg Med Chem. 2017 Feb 1;25(3):886-896. doi: 10.1016/j.bmc.2016.12.002. Epub 2016 Dec 12. Bioorg Med Chem. 2017. PMID: 28011202

4

Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site.

Zhai X, Wang X, Wang J, Liu J, Zuo D, Jiang N, Zeng T, Yang X, Jing T, Gong P. Zhai X, et al. Sci Rep. 2017 Feb 27;7:43398. doi: 10.1038/srep43398. Sci Rep. 2017. PMID: 28240326 Free PMC article.

5

Synthesis, biological evaluation and molecular modeling of imidazo[1,2-a]pyridine derivatives as potent antitubulin agents.

Liu J, Zuo D, Jing T, Guo M, Xing L, Zhang W, Zhao J, Shen J, Gong P, Zhang D, Zhai X. Liu J, et al. Among authors: zhai x. Bioorg Med Chem. 2017 Aug 1;25(15):4088-4099. doi: 10.1016/j.bmc.2017.05.057. Epub 2017 May 30. Bioorg Med Chem. 2017. PMID: 28622907

6

Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R.

Wang Y, Chen S, Hu G, Wang J, Gou W, Zuo D, Gu Y, Gong P, Zhai X. Wang Y, et al. Among authors: zhai x. Eur J Med Chem. 2018 Jan 1;143:123-136. doi: 10.1016/j.ejmech.2017.11.008. Epub 2017 Nov 6. Eur J Med Chem. 2018. PMID: 29174809

7

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells.

Han M, Shen J, Wang L, Wang Y, Zhai X, Li Y, Liu M, Li Z, Zuo D, Wu Y. Han M, et al. Among authors: zhai x. Chem Biol Interact. 2018 Mar 25;284:24-31. doi: 10.1016/j.cbi.2018.02.018. Epub 2018 Feb 16. Chem Biol Interact. 2018. PMID: 29458018

8

CD74-ROS1 G2032R mutation transcriptionally up-regulates Twist1 in non-small cell lung cancer cells leading to increased migration, invasion, and resistance to crizotinib.

Gou W, Zhou X, Liu Z, Wang L, Shen J, Xu X, Li Z, Zhai X, Zuo D, Wu Y. Gou W, et al. Among authors: zhai x. Cancer Lett. 2018 May 28;422:19-28. doi: 10.1016/j.canlet.2018.02.032. Epub 2018 Feb 23. Cancer Lett. 2018. PMID: 29477381

9

Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors.

Jing T, Miao X, Jiang F, Guo M, Xing L, Zhang J, Zuo D, Lei H, Zhai X. Jing T, et al. Among authors: zhai x. Bioorg Med Chem. 2018 May 1;26(8):1784-1796. doi: 10.1016/j.bmc.2018.02.023. Epub 2018 Feb 21. Bioorg Med Chem. 2018. PMID: 29496411

10

Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives.

Guo M, Zuo D, Zhang J, Xing L, Gou W, Jiang F, Jiang N, Zhang D, Zhai X. Guo M, et al. Among authors: zhai x. Eur J Med Chem. 2018 Oct 5;158:322-333. doi: 10.1016/j.ejmech.2018.09.012. Epub 2018 Sep 6. Eur J Med Chem. 2018. PMID: 30223120

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