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Performance of clinicopathologic models in men with high risk localized prostate cancer: impact of a 22-gene genomic classifier.
Tosoian JJ, Birer SR, Jeffrey Karnes R, Zhang J, Davicioni E, Klein EE, Freedland SJ, Weinmann S, Trock BJ, Dess RT, Zhao SG, Jackson WC, Yamoah K, Dal Pra A, Mahal BA, Morgan TM, Mehra R, Kaffenberger S, Salami SS, Kane C, Pollack A, Den RB, Berlin A, Schaeffer EM, Nguyen PL, Feng FY, Spratt DE. Tosoian JJ, et al. Among authors: jeffrey karnes r. Prostate Cancer Prostatic Dis. 2020 Dec;23(4):646-653. doi: 10.1038/s41391-020-0226-2. Epub 2020 Mar 30. Prostate Cancer Prostatic Dis. 2020. PMID: 32231245 Free PMC article.
The presence of extracapsular extension is associated with an increased risk of death from prostate cancer after radical prostatectomy for patients with seminal vesicle invasion and negative lymph nodes.
Mikel Hubanks J, Boorjian SA, Frank I, Gettman MT, Houston Thompson R, Rangel LJ, Bergstralh EJ, Jeffrey Karnes R. Mikel Hubanks J, et al. Among authors: jeffrey karnes r. Urol Oncol. 2014 Jan;32(1):26.e1-7. doi: 10.1016/j.urolonc.2012.09.002. Epub 2013 Feb 6. Urol Oncol. 2014. PMID: 23395235
Current role of surgery for high risk prostate cancer.
Joniau S, Van der Eeckt K, Briganti A, Gontero P, Van Bruwaene S, Jeffrey Karnes R, Spahn M, Van Poppel H; European Multicenter Prostate Cancer Clinical and Translational research Group (EMPaCT). Joniau S, et al. Among authors: jeffrey karnes r. Arch Esp Urol. 2013 Apr;66(3):259-73, 259-74. Arch Esp Urol. 2013. PMID: 23648745 Review. English, Spanish.
Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.
Yang L, Roberts D, Takhar M, Erho N, Bibby BAS, Thiruthaneeswaran N, Bhandari V, Cheng WC, Haider S, McCorry AMB, McArt D, Jain S, Alshalalfa M, Ross A, Schaffer E, Den RB, Jeffrey Karnes R, Klein E, Hoskin PJ, Freedland SJ, Lamb AD, Neal DE, Buffa FM, Bristow RG, Boutros PC, Davicioni E, Choudhury A, West CML. Yang L, et al. Among authors: jeffrey karnes r. EBioMedicine. 2018 May;31:182-189. doi: 10.1016/j.ebiom.2018.04.019. Epub 2018 Apr 23. EBioMedicine. 2018. PMID: 29729848 Free PMC article. Clinical Trial.
Adding carboplatin to chemotherapy regimens for metastatic castrate-resistant prostate cancer in postsecond generation hormone therapy setting: Impact on treatment response and survival outcomes.
Ahmed ME, Andrews JR, Alamiri J, Higa J, Haloi R, Alom M, Motterle G, Joshi V, Shah PH, Jeffrey Karnes R, Kwon E. Ahmed ME, et al. Among authors: jeffrey karnes r. Prostate. 2020 Oct;80(14):1216-1222. doi: 10.1002/pros.24048. Epub 2020 Jul 31. Prostate. 2020. PMID: 32735712
Executive Summary of the American Radium Society Appropriate Use Criteria for Radiation Treatment of Node-Negative Muscle Invasive Bladder Cancer.
Dinh TT, Mitin T, Bagshaw HP, Hoffman KE, Hwang C, Jeffrey Karnes R, Kishan AU, Liauw SL, Lloyd S, Potters L, Showalter TN, Taira AV, Vapiwala N, Zaorsky NG, D'Amico AV, Nguyen PL, Davis BJ. Dinh TT, et al. Among authors: jeffrey karnes r. Int J Radiat Oncol Biol Phys. 2021 Mar 15;109(4):953-963. doi: 10.1016/j.ijrobp.2020.10.031. Epub 2020 Oct 27. Int J Radiat Oncol Biol Phys. 2021. PMID: 33127490
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance.
Arriaga JM, Panja S, Alshalalfa M, Zhao J, Zou M, Giacobbe A, Madubata CJ, Kim JY, Rodriguez A, Coleman I, Virk RK, Hibshoosh H, Ertunc O, Ozbek B, Fountain J, Jeffrey Karnes R, Luo J, Antonarakis ES, Nelson PS, Feng FY, Rubin MA, De Marzo AM, Rabadan R, Sims PA, Mitrofanova A, Abate-Shen C. Arriaga JM, et al. Among authors: jeffrey karnes r. Nat Cancer. 2020 Nov;1(11):1082-1096. doi: 10.1038/s43018-020-00125-0. Epub 2020 Oct 19. Nat Cancer. 2020. PMID: 34085047 Free PMC article.
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.
Qiu X, Boufaied N, Hallal T, Feit A, de Polo A, Luoma AM, Alahmadi W, Larocque J, Zadra G, Xie Y, Gu S, Tang Q, Zhang Y, Syamala S, Seo JH, Bell C, O'Connor E, Liu Y, Schaeffer EM, Jeffrey Karnes R, Weinmann S, Davicioni E, Morrissey C, Cejas P, Ellis L, Loda M, Wucherpfennig KW, Pomerantz MM, Spratt DE, Corey E, Freedman ML, Shirley Liu X, Brown M, Long HW, Labbé DP. Qiu X, et al. Among authors: jeffrey karnes r. Nat Commun. 2022 May 13;13(1):2559. doi: 10.1038/s41467-022-30257-z. Nat Commun. 2022. PMID: 35562350 Free PMC article.
Older patients with low Charlson score and high-risk prostate cancer benefit from radical prostatectomy.
Sivaraman A, Ordaz Jurado G, Cathelineau X, Barret E, Dell'Oglio P, Joniau S, Bianchi M, Briganti A, Spahn M, Bastian P, Chun J, Chlosta P, Gontero P, Graefen M, Jeffrey Karnes R, Marchioro G, Tombal B, Tosco L, van der Poel HH, Sanchez-Salas R. Sivaraman A, et al. Among authors: jeffrey karnes r. World J Urol. 2016 Oct;34(10):1367-72. doi: 10.1007/s00345-016-1784-8. Epub 2016 Feb 20. World J Urol. 2016. PMID: 26897499 Free article.
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