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Page 1
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors.
Manganaro R, Zonsics B, Bauer L, Lorenzo Lopez M, Donselaar T, Zwaagstra M, Saporito F, Ferla S, Strating JRPM, Coutard B, Hurdiss DL, van Kuppeveld FJM, Brancale A. Manganaro R, et al. Among authors: donselaar t. Antiviral Res. 2020 Jun;178:104781. doi: 10.1016/j.antiviral.2020.104781. Epub 2020 Mar 29. Antiviral Res. 2020. PMID: 32234539
Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C.
Bauer L, Manganaro R, Zonsics B, Hurdiss DL, Zwaagstra M, Donselaar T, Welter NGE, van Kleef RGDM, Lopez ML, Bevilacqua F, Raman T, Ferla S, Bassetto M, Neyts J, Strating JRPM, Westerink RHS, Brancale A, van Kuppeveld FJM. Bauer L, et al. Among authors: donselaar t. PLoS Biol. 2020 Nov 6;18(11):e3000904. doi: 10.1371/journal.pbio.3000904. eCollection 2020 Nov. PLoS Biol. 2020. PMID: 33156822 Free PMC article.
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss DL, El Kazzi P, Bauer L, Papageorgiou N, Ferron FP, Donselaar T, van Vliet ALW, Shamorkina TM, Snijder J, Canard B, Decroly E, Brancale A, Zeev-Ben-Mordehai T, Förster F, van Kuppeveld FJM, Coutard B. Hurdiss DL, et al. Among authors: donselaar t. Sci Adv. 2022 Jan 7;8(1):eabj7615. doi: 10.1126/sciadv.abj7615. Epub 2022 Jan 5. Sci Adv. 2022. PMID: 34985963 Free PMC article.
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein.
Thijssen V, Hurdiss DL, Debski-Antoniak OJ, Spence MA, Franck C, Norman A, Aggarwal A, Mokiem NJ, van Dongen DAA, Vermeir SW, Liu M, Li W, Chatziandreou M, Donselaar T, Du W, Drulyte I, Bosch BJ, Snijder J, Turville SG, Payne RJ, Jackson CJ, van Kuppeveld FJM, Jongkees SAK. Thijssen V, et al. Among authors: donselaar t. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2303292120. doi: 10.1073/pnas.2303292120. Epub 2023 Jun 20. Proc Natl Acad Sci U S A. 2023. PMID: 37339194 Free PMC article.