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Page 1
Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.
Berner DK, Wessolowski L, Armbrust F, Schneppenheim J, Schlepckow K, Koudelka T, Scharfenberg F, Lucius R, Tholey A, Kleinberger G, Haass C, Arnold P, Becker-Pauly C. Berner DK, et al. Among authors: scharfenberg f. FASEB J. 2020 May;34(5):6675-6687. doi: 10.1096/fj.201902183R. Epub 2020 Apr 1. FASEB J. 2020. PMID: 32237095
Meprin β and BMP-1 are differentially regulated by CaCl2.
Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P. Schneppenheim J, et al. Among authors: scharfenberg f. Cell Calcium. 2017 Jul;65:8-13. doi: 10.1016/j.ceca.2017.03.005. Epub 2017 Mar 19. Cell Calcium. 2017. PMID: 28365001
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.
Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C. Peters F, et al. Among authors: scharfenberg f. FASEB J. 2019 Jun;33(6):7490-7504. doi: 10.1096/fj.201802391R. Epub 2019 Mar 27. FASEB J. 2019. PMID: 30916990 Free PMC article.
Comparison of the transcriptional gene analysis data with gene analyses of IBD patients revealed that different gene subsets were dysregulated if meprin alpha was expressed alone or in the enzyme complex, demonstrating the physiologic and pathophysiological relevance of the mepri …
Comparison of the transcriptional gene analysis data with gene analyses of IBD patients revealed that different gene subsets were dysregulat …
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C. Scharfenberg F, et al. Cell Mol Life Sci. 2020 Jan;77(2):331-350. doi: 10.1007/s00018-019-03184-4. Epub 2019 Jun 17. Cell Mol Life Sci. 2020. PMID: 31209506 Free PMC article.
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C. Wichert R, et al. Among authors: scharfenberg f. FASEB J. 2019 Nov;33(11):11925-11940. doi: 10.1096/fj.201801371R. Epub 2019 Aug 9. FASEB J. 2019. PMID: 31381863 Free PMC article.
Thus, we identified a novel proteolytic pathway of meprin beta with ADAM proteases to control protease activities at the cell surface as part of the protease web.-Wichert, R., Scharfenberg, F., Colmorgen, C., Koudelka, T., Schwarz, J., Wetzel, S., Potempa, B., Potem …
Thus, we identified a novel proteolytic pathway of meprin beta with ADAM proteases to control protease activities at the cell surface as par …
Meprin β: A novel regulator of blood-brain barrier integrity.
Gindorf M, Storck SE, Ohler A, Scharfenberg F, Becker-Pauly C, Pietrzik CU. Gindorf M, et al. Among authors: scharfenberg f. J Cereb Blood Flow Metab. 2021 Jan;41(1):31-44. doi: 10.1177/0271678X20905206. Epub 2020 Feb 16. J Cereb Blood Flow Metab. 2021. PMID: 32065075 Free PMC article.
Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R.
Gellrich A, Scharfenberg F, Peters F, Sammel M, Helm O, Armbrust F, Schmidt F, Lokau J, Garbers C, Sebens S, Arnold P, Becker-Pauly C. Gellrich A, et al. Among authors: scharfenberg f. Front Mol Biosci. 2021 Oct 6;8:702341. doi: 10.3389/fmolb.2021.702341. eCollection 2021. Front Mol Biosci. 2021. PMID: 34692768 Free PMC article.
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