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Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.
Webster CI, Caram-Salas N, Haqqani AS, Thom G, Brown L, Rennie K, Yogi A, Costain W, Brunette E, Stanimirovic DB. Webster CI, et al. Among authors: yogi a. FASEB J. 2016 May;30(5):1927-40. doi: 10.1096/fj.201500078. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839377
Both BBB-NiP and BBB-mGluR1 demonstrated a similar 20-fold enhanced rate of transcytosis across an in vitro BBB model compared with mGluR1 IgG fused to a control antibody fragment. ...-Webster, C. I., Caram-Salas, N., Haqqani, A. S., Thom, G., Brown, L., Renn …
Both BBB-NiP and BBB-mGluR1 demonstrated a similar 20-fold enhanced rate of transcytosis across an in vitro BBB model compared with m …
89 results