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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE. Whitesell L, et al. Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w. Nat Commun. 2019. PMID: 30679438 Free PMC article.
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: whitesell l. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability.
Liston SD, Whitesell L, McLellan CA, Mazitschek R, Petraitis V, Petraitiene R, Kavaliauskas P, Walsh TJ, Cowen LE. Liston SD, et al. Among authors: whitesell l. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00899-20. doi: 10.1128/AAC.00899-20. Print 2020 Sep 21. Antimicrob Agents Chemother. 2020. PMID: 32661007 Free PMC article.
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.
Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. Iyer KR, et al. Among authors: whitesell l. Nat Commun. 2020 Dec 22;11(1):6429. doi: 10.1038/s41467-020-20183-3. Nat Commun. 2020. PMID: 33353950 Free PMC article.
179 results