Patel JP - Search Results

1

Discovery and Optimization of Glucose Uptake Inhibitors.

Liu KG, Kim JI, Olszewski K, Barsotti AM, Morris K, Lamarque C, Yu X, Gaffney J, Feng XJ, Patel JP, Poyurovsky MV. Liu KG, et al. Among authors: patel jp. J Med Chem. 2020 May 28;63(10):5201-5211. doi: 10.1021/acs.jmedchem.9b02153. Epub 2020 May 8. J Med Chem. 2020. PMID: 32282207

2

Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.

Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. Olszewski K, et al. Among authors: patel jp. Cell Chem Biol. 2022 Mar 17;29(3):423-435.e10. doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 28. Cell Chem Biol. 2022. PMID: 34715056 Free article.

3

Functional antibody characterization via direct structural analysis and information-driven protein-protein docking.

Depetris RS, Lu D, Polonskaya Z, Zhang Z, Luna X, Tankard A, Kolahi P, Drummond M, Williams C, Ebert MCCJC, Patel JP, Poyurovsky MV. Depetris RS, et al. Among authors: patel jp. Proteins. 2022 Apr;90(4):919-935. doi: 10.1002/prot.26280. Epub 2021 Nov 25. Proteins. 2022. PMID: 34773424 Free PMC article.

4

A Phase 1 Thorough QT/QTc Study of Therapeutic and Supratherapeutic Doses of Belumosudil in Healthy Subjects.

Schueller O, Lohmer L, Xue H, Darpo B, Patel J. Schueller O, et al. Clin Pharmacol Drug Dev. 2022 Oct;11(10):1221-1232. doi: 10.1002/cpdd.1142. Epub 2022 Jul 26. Clin Pharmacol Drug Dev. 2022. PMID: 35881051 Clinical Trial.

5

Single-Dose Anti-PD-L1/IL-15 Fusion Protein KD033 Generates Synergistic Antitumor Immunity with Robust Tumor-Immune Gene Signatures and Memory Responses.

Martomo SA, Lu D, Polonskaya Z, Luna X, Zhang Z, Feldstein S, Lumban-Tobing R, Almstead DK, Miyara F, Patel J. Martomo SA, et al. Mol Cancer Ther. 2021 Feb;20(2):347-356. doi: 10.1158/1535-7163.MCT-20-0457. Epub 2020 Dec 8. Mol Cancer Ther. 2021. PMID: 33293344

6

A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors.

Schueller O, Willson A, Singh N, Lohmer L, Alabanza A, Patel J. Schueller O, et al. Clin Pharmacol Drug Dev. 2022 Jul;11(7):795-806. doi: 10.1002/cpdd.1082. Epub 2022 Mar 1. Clin Pharmacol Drug Dev. 2022. PMID: 35230741 Clinical Trial.

7

ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease.

Jagasia M, Lazaryan A, Bachier CR, Salhotra A, Weisdorf DJ, Zoghi B, Essell J, Green L, Schueller O, Patel J, Zanin-Zhorov A, Weiss JM, Yang Z, Eiznhamer D, Aggarwal SK, Blazar BR, Lee SJ. Jagasia M, et al. J Clin Oncol. 2021 Jun 10;39(17):1888-1898. doi: 10.1200/JCO.20.02754. Epub 2021 Apr 20. J Clin Oncol. 2021. PMID: 33877856 Free PMC article. Clinical Trial.

8

Evaluation of the clinical molecule anti-human-PD-L1/IL-15 KD033 in the human-PD-1/PD-L1-expressing murine model demonstrates PD-L1 targeting of IL-15 in vivo.

Martomo SA, Patel J. Martomo SA, et al. Cancer Immunol Immunother. 2023 Jun;72(6):1941-1950. doi: 10.1007/s00262-022-03331-0. Epub 2022 Dec 1. Cancer Immunol Immunother. 2023. PMID: 36454338 Free PMC article.

9

Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects.

Schueller O, McDermott J, Evans P, Lohmer L, Alabanza A, Patel J. Schueller O, et al. Clin Pharmacol Drug Dev. 2022 Jul;11(7):807-814. doi: 10.1002/cpdd.1083. Epub 2022 Mar 2. Clin Pharmacol Drug Dev. 2022. PMID: 35238174 Clinical Trial.

10

Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [¹⁴ C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study.

Schueller O, Skucas E, Regev G, Shaw I, Singh N, Sanghvi M, Croft M, Lohmer L, Alabanza A, Patel J. Schueller O, et al. Clin Pharmacol Drug Dev. 2022 Jul;11(7):786-794. doi: 10.1002/cpdd.1085. Epub 2022 Mar 1. Clin Pharmacol Drug Dev. 2022. PMID: 35231159 Clinical Trial.

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