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LRP1 is a master regulator of tau uptake and spread.
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. Rauch JN, et al. Among authors: kampmann m. Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296178 Free PMC article.
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.
Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Chen JJ, et al. Among authors: kampmann m. J Biol Chem. 2019 Dec 13;294(50):18952-18966. doi: 10.1074/jbc.RA119.009432. Epub 2019 Oct 2. J Biol Chem. 2019. PMID: 31578281 Free PMC article.
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group. Karch CM, et al. Stem Cell Reports. 2019 Nov 12;13(5):939-955. doi: 10.1016/j.stemcr.2019.09.006. Epub 2019 Oct 17. Stem Cell Reports. 2019. PMID: 31631020 Free PMC article.
Gene expression and cell identity controlled by anaphase-promoting complex.
Oh E, Mark KG, Mocciaro A, Watson ER, Prabu JR, Cha DD, Kampmann M, Gamarra N, Zhou CY, Rape M. Oh E, et al. Among authors: kampmann m. Nature. 2020 Mar;579(7797):136-140. doi: 10.1038/s41586-020-2034-1. Epub 2020 Feb 19. Nature. 2020. PMID: 32076268 Free PMC article.
Molecular characterization of selectively vulnerable neurons in Alzheimer's disease.
Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M. Leng K, et al. Among authors: kampmann m. Nat Neurosci. 2021 Feb;24(2):276-287. doi: 10.1038/s41593-020-00764-7. Epub 2021 Jan 11. Nat Neurosci. 2021. PMID: 33432193 Free PMC article.
Patterns of neuronal Rhes as a novel hallmark of tauopathies.
Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. Ehrenberg AJ, et al. Among authors: kampmann m. Acta Neuropathol. 2021 May;141(5):651-666. doi: 10.1007/s00401-021-02279-2. Epub 2021 Mar 7. Acta Neuropathol. 2021. PMID: 33677647 Free PMC article.
178 results