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A multicenter, randomized, placebo-controlled, double-blind phase 3 trial with open-arm comparison indicates safety and efficacy of nephroprotective therapy with ramipril in children with Alport's syndrome.
Gross O, Tönshoff B, Weber LT, Pape L, Latta K, Fehrenbach H, Lange-Sperandio B, Zappel H, Hoyer P, Staude H, König S, John U, Gellermann J, Hoppe B, Galiano M, Hoecker B, Ehren R, Lerch C, Kashtan CE, Harden M, Boeckhaus J, Friede T; German Pediatric Nephrology (GPN) Study Group and EARLY PRO-TECT Alport Investigators. Gross O, et al. Among authors: kashtan ce. Kidney Int. 2020 Jun;97(6):1275-1286. doi: 10.1016/j.kint.2019.12.015. Epub 2020 Jan 17. Kidney Int. 2020. PMID: 32299679 Free article. Clinical Trial.
Treatment of Alport syndrome: beyond animal models.
Gross O, Kashtan CE. Gross O, et al. Among authors: kashtan ce. Kidney Int. 2009 Sep;76(6):599-603. doi: 10.1038/ki.2009.223. Epub 2009 Jun 17. Kidney Int. 2009. PMID: 19536083 Free article. Review.
The 2014International Workshop on Alport Syndrome.
Miner JH, Baigent C, Flinter F, Gross O, Judge P, Kashtan CE, Lagas S, Savige J, Blatt D, Ding J, Gale DP, Midgley JP, Povey S, Prunotto M, Renault D, Skelding J, Turner AN, Gear S. Miner JH, et al. Among authors: kashtan ce. Kidney Int. 2014 Oct;86(4):679-84. doi: 10.1038/ki.2014.229. Epub 2014 Jul 2. Kidney Int. 2014. PMID: 24988067 Free PMC article.
Clinical trial recommendations for potential Alport syndrome therapies.
Weinstock BA, Feldman DL, Fornoni A, Gross O, Kashtan CE, Lagas S, Lennon R, Miner JH, Rheault MN, Simon JF; Workshop Participants. Weinstock BA, et al. Among authors: kashtan ce. Kidney Int. 2020 Jun;97(6):1109-1116. doi: 10.1016/j.kint.2020.02.029. Epub 2020 Apr 6. Kidney Int. 2020. PMID: 32386680 Free PMC article.
129 results