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Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs.
Smedley CJ, Li G, Barrow AS, Gialelis TL, Giel MC, Ottonello A, Cheng Y, Kitamura S, Wolan DW, Sharpless KB, Moses JE. Smedley CJ, et al. Among authors: li g. Angew Chem Int Ed Engl. 2020 Jul 20;59(30):12460-12469. doi: 10.1002/anie.202003219. Epub 2020 Jun 4. Angew Chem Int Ed Engl. 2020. PMID: 32301265 Free PMC article.
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.
Liu Z, Li J, Li S, Li G, Sharpless KB, Wu P. Liu Z, et al. Among authors: li s, li j, li g. J Am Chem Soc. 2018 Feb 28;140(8):2919-2925. doi: 10.1021/jacs.7b12788. Epub 2018 Feb 16. J Am Chem Soc. 2018. PMID: 29451783 Free PMC article.
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB. Zheng Q, et al. Among authors: li g. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18808-18814. doi: 10.1073/pnas.1909972116. Epub 2019 Sep 4. Proc Natl Acad Sci U S A. 2019. PMID: 31484779 Free PMC article.
SuFExable polymers with helical structures derived from thionyl tetrafluoride.
Li S, Li G, Gao B, Pujari SP, Chen X, Kim H, Zhou F, Klivansky LM, Liu Y, Driss H, Liang DD, Lu J, Wu P, Zuilhof H, Moses J, Sharpless KB. Li S, et al. Among authors: li g. Nat Chem. 2021 Sep;13(9):858-867. doi: 10.1038/s41557-021-00726-x. Epub 2021 Aug 16. Nat Chem. 2021. PMID: 34400816 Free PMC article.
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.
Cheng Y, Li G, Smedley CJ, Giel MC, Kitamura S, Woehl JL, Bianco G, Forli S, Homer JA, Cappiello JR, Wolan DW, Moses JE, Sharpless KB. Cheng Y, et al. Among authors: li g. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2208540119. doi: 10.1073/pnas.2208540119. Epub 2022 Sep 7. Proc Natl Acad Sci U S A. 2022. PMID: 36070343 Free PMC article.
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