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The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.
Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM, Turner AJ. Belyaev ND, et al. Among authors: hooper nm. J Biol Chem. 2010 Dec 31;285(53):41443-54. doi: 10.1074/jbc.M110.141390. Epub 2010 Oct 20. J Biol Chem. 2010. PMID: 20961856 Free PMC article.
Regulation of amyloid-β production by the prion protein.
Griffiths HH, Whitehouse IJ, Hooper NM. Griffiths HH, et al. Among authors: hooper nm. Prion. 2012 Jul 1;6(3):217-22. doi: 10.4161/pri.18988. Epub 2012 Jul 1. Prion. 2012. PMID: 22449984 Free PMC article.
291 results