Hou Y - Search Results

1

Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity.

Qin M, Tian Y, Han X, Cao Q, Zheng S, Liu C, Wu X, Liu L, Meng Y, Wang X, Zhang H, Hou Y. Qin M, et al. Among authors: hou y. Bioorg Med Chem. 2020 Jun 1;28(11):115486. doi: 10.1016/j.bmc.2020.115486. Epub 2020 Apr 3. Bioorg Med Chem. 2020. PMID: 32305182

2

Discovery of a novel 6,7-disubstituted-4-(2-fluorophenoxy)quinolines bearing 1,2,3-triazole-4-carboxamide moiety as potent c-Met kinase inhibitors.

Liu M, Hou Y, Yin W, Zhou S, Qian P, Guo Z, Xu L, Zhao Y. Liu M, et al. Among authors: hou y. Eur J Med Chem. 2016 Aug 25;119:96-108. doi: 10.1016/j.ejmech.2016.04.035. Epub 2016 Apr 23. Eur J Med Chem. 2016. PMID: 27155466

3

Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents.

Hou Y, Zhu L, Li Z, Shen Q, Xu Q, Li W, Liu Y, Gong P. Hou Y, et al. Eur J Med Chem. 2019 Feb 1;163:690-709. doi: 10.1016/j.ejmech.2018.12.009. Epub 2018 Dec 10. Eur J Med Chem. 2019. PMID: 30572179

4

Design, synthesis, and biological evaluation of 4-((6,7-dimethoxyquinoline-4-yl)oxy)aniline derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia.

Xu Q, Dai B, Li Z, Xu L, Yang D, Gong P, Hou Y, Liu Y. Xu Q, et al. Among authors: hou y. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126630. doi: 10.1016/j.bmcl.2019.126630. Epub 2019 Aug 20. Bioorg Med Chem Lett. 2019. PMID: 31466809

5

Design, synthesis, and biological evaluation of 4-phenoxyquinoline derivatives as potent c-Met kinase inhibitor.

Yang Y, Li Y, Hou Y, Qin M, Gong P, Liu J, Zhao Y. Yang Y, et al. Among authors: hou y. Bioorg Med Chem Lett. 2019 Dec 1;29(23):126666. doi: 10.1016/j.bmcl.2019.126666. Epub 2019 Sep 3. Bioorg Med Chem Lett. 2019. PMID: 31629631

6

Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.

Hou Y, Dong Y, Ye T, Jiang J, Ding L, Qin M, Ding X, Zhao Y. Hou Y, et al. Bioorg Med Chem Lett. 2019 Dec 1;29(23):126746. doi: 10.1016/j.bmcl.2019.126746. Epub 2019 Oct 19. Bioorg Med Chem Lett. 2019. PMID: 31676225

7

Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold.

Qin M, Cao Q, Wu X, Liu C, Zheng S, Xie H, Tian Y, Xie J, Zhao Y, Hou Y, Zhang X, Xu B, Zhang H, Wang X. Qin M, et al. Among authors: hou y. Eur J Med Chem. 2020 Jan 15;186:111856. doi: 10.1016/j.ejmech.2019.111856. Epub 2019 Nov 9. Eur J Med Chem. 2020. PMID: 31734021

8

Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors.

Liu J, Gong Y, Shi J, Hao X, Wang Y, Zhou Y, Hou Y, Liu Y, Ding S, Chen Y. Liu J, et al. Among authors: hou y. Eur J Med Chem. 2020 May 15;194:112244. doi: 10.1016/j.ejmech.2020.112244. Epub 2020 Mar 20. Eur J Med Chem. 2020. PMID: 32224380

9

Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents.

Ye T, Han Y, Wang R, Yan P, Chen S, Hou Y, Zhao Y. Ye T, et al. Among authors: hou y. Bioorg Chem. 2020 Jun;99:103796. doi: 10.1016/j.bioorg.2020.103796. Epub 2020 Mar 31. Bioorg Chem. 2020. PMID: 32283346

10

Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors.

Li Z, Xu L, Zhu L, Zhao Y, Hu T, Yin B, Liu Y, Hou Y. Li Z, et al. Among authors: hou y. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127329. doi: 10.1016/j.bmcl.2020.127329. Epub 2020 Jun 8. Bioorg Med Chem Lett. 2020. PMID: 32631534

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