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Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.
Boel A, Burger J, Vanhomwegen M, Beyens A, Renard M, Barnhoorn S, Casteleyn C, Reinhardt DP, Descamps B, Vanhove C, van der Pluijm I, Coucke P, Willaert A, Essers J, Callewaert B. Boel A, et al. Among authors: barnhoorn s. Hum Mol Genet. 2020 Jun 3;29(9):1476-1488. doi: 10.1093/hmg/ddaa071. Hum Mol Genet. 2020. PMID: 32307537
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.
Barnhoorn S, Uittenboogaard LM, Jaarsma D, Vermeij WP, Tresini M, Weymaere M, Menoni H, Brandt RM, de Waard MC, Botter SM, Sarker AH, Jaspers NG, van der Horst GT, Cooper PK, Hoeijmakers JH, van der Pluijm I. Barnhoorn S, et al. PLoS Genet. 2014 Oct 9;10(10):e1004686. doi: 10.1371/journal.pgen.1004686. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25299392 Free PMC article.
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.
Visser WE, Bombardieri CR, Zevenbergen C, Barnhoorn S, Ottaviani A, van der Pluijm I, Brandt R, Kaptein E, van Heerebeek R, van Toor H, Garinis GA, Peeters RP, Medici M, van Ham W, Vermeij WP, de Waard MC, de Krijger RR, Boelen A, Kwakkel J, Kopchick JJ, List EO, Melis JP, Darras VM, Dollé ME, van der Horst GT, Hoeijmakers JH, Visser TJ. Visser WE, et al. Among authors: barnhoorn s. PLoS One. 2016 Mar 8;11(3):e0149941. doi: 10.1371/journal.pone.0149941. eCollection 2016. PLoS One. 2016. PMID: 26953569 Free PMC article.
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice.
de Boer M, Te Lintel Hekkert M, Chang J, van Thiel BS, Martens L, Bos MM, de Kleijnen MGJ, Ridwan Y, Octavia Y, van Deel ED, Blonden LA, Brandt RMC, Barnhoorn S, Bautista-Niño PK, Krabbendam-Peters I, Wolswinkel R, Arshi B, Ghanbari M, Kupatt C, de Windt LJ, Danser AHJ, van der Pluijm I, Remme CA, Stoll M, Pothof J, Roks AJM, Kavousi M, Essers J, van der Velden J, Hoeijmakers JHJ, Duncker DJ. de Boer M, et al. Among authors: barnhoorn s. Aging Cell. 2023 Mar;22(3):e13768. doi: 10.1111/acel.13768. Epub 2023 Feb 8. Aging Cell. 2023. PMID: 36756698 Free PMC article.
Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.
Alyodawi K, Vermeij WP, Omairi S, Kretz O, Hopkinson M, Solagna F, Joch B, Brandt RMC, Barnhoorn S, van Vliet N, Ridwan Y, Essers J, Mitchell R, Morash T, Pasternack A, Ritvos O, Matsakas A, Collins-Hooper H, Huber TB, Hoeijmakers JHJ, Patel K. Alyodawi K, et al. Among authors: barnhoorn s. J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):662-686. doi: 10.1002/jcsm.12404. Epub 2019 Mar 27. J Cachexia Sarcopenia Muscle. 2019. PMID: 30916493 Free PMC article.
Genome-wide RNA polymerase stalling shapes the transcriptome during aging.
Gyenis A, Chang J, Demmers JJPG, Bruens ST, Barnhoorn S, Brandt RMC, Baar MP, Raseta M, Derks KWJ, Hoeijmakers JHJ, Pothof J. Gyenis A, et al. Among authors: barnhoorn s. Nat Genet. 2023 Feb;55(2):268-279. doi: 10.1038/s41588-022-01279-6. Epub 2023 Jan 19. Nat Genet. 2023. PMID: 36658433 Free PMC article.
Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice.
van Beek AA, Hugenholtz F, Meijer B, Sovran B, Perdijk O, Vermeij WP, Brandt RM, Barnhoorn S, Hoeijmakers JH, de Vos P, Leenen PJ, Hendriks RW, Savelkoul HF. van Beek AA, et al. Among authors: barnhoorn s. J Leukoc Biol. 2017 Apr;101(4):811-821. doi: 10.1189/jlb.1HI0216-062RR. Epub 2016 Jul 14. J Leukoc Biol. 2017. PMID: 27418353 Free PMC article.
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