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Page 1
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies.
Oostindie SC, van der Horst HJ, Kil LP, Strumane K, Overdijk MB, van den Brink EN, van den Brakel JHN, Rademaker HJ, van Kessel B, van den Noort J, Chamuleau MED, Mutis T, Lindorfer MA, Taylor RP, Schuurman J, Parren PWHI, Beurskens FJ, Breij ECW. Oostindie SC, et al. Blood Cancer J. 2020 Apr 28;10(3):30. doi: 10.1038/s41408-020-0292-7. Blood Cancer J. 2020. PMID: 32341336 Free PMC article.
A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.
de Jong RN, Beurskens FJ, Verploegen S, Strumane K, van Kampen MD, Voorhorst M, Horstman W, Engelberts PJ, Oostindie SC, Wang G, Heck AJ, Schuurman J, Parren PW. de Jong RN, et al. Among authors: oostindie sc. PLoS Biol. 2016 Jan 6;14(1):e1002344. doi: 10.1371/journal.pbio.1002344. eCollection 2016 Jan. PLoS Biol. 2016. PMID: 26736041 Free PMC article.
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.
Oostindie SC, van der Horst HJ, Lindorfer MA, Cook EM, Tupitza JC, Zent CS, Burack R, VanDerMeid KR, Strumane K, Chamuleau MED, Mutis T, de Jong RN, Schuurman J, Breij ECW, Beurskens FJ, Parren PWHI, Taylor RP. Oostindie SC, et al. Haematologica. 2019 Sep;104(9):1841-1852. doi: 10.3324/haematol.2018.207266. Epub 2019 Feb 21. Haematologica. 2019. PMID: 30792198 Free PMC article.
DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.
Engelberts PJ, Hiemstra IH, de Jong B, Schuurhuis DH, Meesters J, Beltran Hernandez I, Oostindie SC, Neijssen J, van den Brink EN, Horbach GJ, Verploegen S, Labrijn AF, Salcedo T, Schuurman J, Parren PWHI, Breij ECW. Engelberts PJ, et al. Among authors: oostindie sc. EBioMedicine. 2020 Feb;52:102625. doi: 10.1016/j.ebiom.2019.102625. Epub 2020 Jan 23. EBioMedicine. 2020. PMID: 31981978 Free PMC article.
Potent Preclinical Efficacy of DuoHexaBody-CD37 in B-Cell Malignancies.
van der Horst HJ, Oostindie SC, Cillessen SAGM, Gelderloos AT, Overdijk MB, Nijhof IS, Zweegman S, Chamuleau MED, Breij ECW, Mutis T. van der Horst HJ, et al. Among authors: oostindie sc. Hemasphere. 2020 Dec 9;5(1):e504. doi: 10.1097/HS9.0000000000000504. eCollection 2021 Jan. Hemasphere. 2020. PMID: 33324950 Free PMC article.
Carbamylation reduces the capacity of IgG for hexamerization and complement activation.
Lubbers R, Oostindie SC, Dijkstra DJ, Parren PWHI, Verheul MK, Abendstein L, Sharp TH, de Ru A, Janssen GMC, van Veelen PA, van den Bremer ETJ, Bleijlevens B, de Kreuk BJ, Beurskens FJ, Trouw LA. Lubbers R, et al. Among authors: oostindie sc. Clin Exp Immunol. 2020 Apr;200(1):1-11. doi: 10.1111/cei.13411. Epub 2020 Jan 5. Clin Exp Immunol. 2020. PMID: 31853959 Free PMC article.
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens.
Oostindie SC, Rinaldi DA, Zom GG, Wester MJ, Paulet D, Al-Tamimi K, van der Meijden E, Scheick JR, Wilpshaar T, de Jong B, Hoff-van den Broek M, Grattan RM, Oosterhoff JJ, Vignau J, Verploegen S, Boross P, Beurskens FJ, Lidke DS, Schuurman J, de Jong RN. Oostindie SC, et al. Nat Biotechnol. 2022 Oct;40(10):1509-1519. doi: 10.1038/s41587-022-01384-1. Epub 2022 Jul 25. Nat Biotechnol. 2022. PMID: 35879362 Free PMC article.