Portoghese PS - Search Results

1

The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids.

Speltz R, Lunzer MM, Shueb SS, Akgün E, Reed R, Kalyuzhny A, Portoghese PS, Simone DA. Speltz R, et al. Among authors: portoghese ps. Pain. 2020 Sep 1;161(9):2041-2057. doi: 10.1097/j.pain.0000000000001902. Pain. 2020. PMID: 32345918 Free PMC article.

2

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS. Le Naour M, et al. Among authors: portoghese ps. J Med Chem. 2013 Jul 11;56(13):5505-13. doi: 10.1021/jm4005219. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23734559 Free PMC article.

3

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.

Akgün E, Javed MI, Lunzer MM, Smeester BA, Beitz AJ, Portoghese PS. Akgün E, et al. Among authors: portoghese ps. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11595-9. doi: 10.1073/pnas.1305461110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798416 Free PMC article.

4

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model.

Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS. Smeester BA, et al. Among authors: portoghese ps. Eur J Pharmacol. 2014 Nov 15;743:48-52. doi: 10.1016/j.ejphar.2014.09.008. Epub 2014 Sep 17. Eur J Pharmacol. 2014. PMID: 25239072 Free PMC article.

5

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS. Akgün E, et al. Among authors: portoghese ps. J Med Chem. 2015 Nov 12;58(21):8647-57. doi: 10.1021/acs.jmedchem.5b01245. Epub 2015 Oct 20. J Med Chem. 2015. PMID: 26451468 Free PMC article.

6

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese PS, Akgün E, Lunzer MM. Portoghese PS, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):426-428. doi: 10.1021/acschemneuro.7b00002. Epub 2017 Jan 31. ACS Chem Neurosci. 2017. PMID: 28139906

7

Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice.

Peterson CD, Kitto KF, Akgün E, Lunzer MM, Riedl MS, Vulchanova L, Wilcox GL, Portoghese PS, Fairbanks CA. Peterson CD, et al. Among authors: portoghese ps. Pain. 2017 Dec;158(12):2431-2441. doi: 10.1097/j.pain.0000000000001050. Pain. 2017. PMID: 28891868 Free PMC article.

8

Bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease.

Cataldo G, Lunzer MM, Olson JK, Akgün E, Belcher JD, Vercellotti GM, Portoghese PS, Simone DA. Cataldo G, et al. Among authors: portoghese ps. Pain. 2018 Jul;159(7):1382-1391. doi: 10.1097/j.pain.0000000000001225. Pain. 2018. PMID: 29578946 Free PMC article.

9

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance.

Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA. Dutta R, et al. Among authors: portoghese ps. Arthritis Res Ther. 2018 Jul 27;20(1):154. doi: 10.1186/s13075-018-1661-5. Arthritis Res Ther. 2018. PMID: 30053832 Free PMC article.

10

Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance.

Akgün E, Lunzer MM, Portoghese PS. Akgün E, et al. Among authors: portoghese ps. ACS Chem Neurosci. 2019 Apr 17;10(4):2004-2011. doi: 10.1021/acschemneuro.8b00323. Epub 2018 Aug 24. ACS Chem Neurosci. 2019. PMID: 30110531

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