Gough A - Search Results

1

Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy.

Nmezi B, Vollmer LL, Shun TY, Gough A, Rolyan H, Liu F, Jia Y, Padiath QS, Vogt A. Nmezi B, et al. Among authors: gough a. SLAS Discov. 2020 Sep;25(8):939-949. doi: 10.1177/2472555220915821. Epub 2020 Apr 30. SLAS Discov. 2020. PMID: 32349647 Free PMC article.

2

In vitro platforms for evaluating liver toxicity.

Bale SS, Vernetti L, Senutovitch N, Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta BO, Taylor DL, Yarmush ML. Bale SS, et al. Among authors: gough a. Exp Biol Med (Maywood). 2014 Sep;239(9):1180-1191. doi: 10.1177/1535370214531872. Epub 2014 Apr 24. Exp Biol Med (Maywood). 2014. PMID: 24764241 Free PMC article. Review.

3

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL. Gough AH, et al. PLoS One. 2014 Jul 18;9(7):e102678. doi: 10.1371/journal.pone.0102678. eCollection 2014. PLoS One. 2014. PMID: 25036749 Free PMC article.

4

A human liver microphysiology platform for investigating physiology, drug safety, and disease models.

Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL. Vernetti LA, et al. Among authors: gough a. Exp Biol Med (Maywood). 2016 Jan;241(1):101-14. doi: 10.1177/1535370215592121. Epub 2015 Jul 22. Exp Biol Med (Maywood). 2016. PMID: 26202373 Free PMC article.

5

A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screens.

Gough A, Shun TY, Lansing Taylor D, Schurdak M. Gough A, et al. Methods. 2016 Mar 1;96:12-26. doi: 10.1016/j.ymeth.2015.10.007. Epub 2015 Nov 4. Methods. 2016. PMID: 26476369 Free PMC article.

6

Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy.

Vernetti LA, Vogt A, Gough A, Taylor DL. Vernetti LA, et al. Among authors: gough a. Clin Liver Dis. 2017 Feb;21(1):197-214. doi: 10.1016/j.cld.2016.08.013. Clin Liver Dis. 2017. PMID: 27842772 Free PMC article. Review.

7

Biologically Relevant Heterogeneity: Metrics and Practical Insights.

Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL. Gough A, et al. SLAS Discov. 2017 Mar;22(3):213-237. doi: 10.1177/2472555216682725. Epub 2017 Jan 6. SLAS Discov. 2017. PMID: 28231035 Free PMC article. Review.

8

The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models.

Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL. Gough A, et al. Appl In Vitro Toxicol. 2016 Jun 1;2(2):103-117. doi: 10.1089/aivt.2016.0011. Appl In Vitro Toxicol. 2016. PMID: 28781990 Free PMC article.

9

Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos.

Shun T, Gough AH, Sanker S, Hukriede NA, Vogt A. Shun T, et al. Among authors: gough ah. Assay Drug Dev Technol. 2017 Aug/Sep;15(6):257-266. doi: 10.1089/adt.2017.793. Epub 2017 Aug 11. Assay Drug Dev Technol. 2017. PMID: 28800244 Free PMC article.

10

Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies.

Gough A, Shun TY, Taylor DL, Schurdak M. Gough A, et al. Methods Mol Biol. 2018;1745:25-46. doi: 10.1007/978-1-4939-7680-5_2. Methods Mol Biol. 2018. PMID: 29476461

Heterogeneity is a complex property of cellular systems and therefore presents challenges to the reliable identification and characterization. ...Previously, we demonstrated the use of the Kolmogorov-Smirnov statistic as a metric for monitoring the reproducibility o …

Heterogeneity is a complex property of cellular systems and therefore presents challenges to the reliable identification and characte …

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