Chen W - Search Results

1

Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase.

Liu Z, Hu Q, Wang W, Lu S, Wu D, Ze S, He J, Huang Y, Chen W, Xu Y, Lu W, Huang J. Liu Z, et al. Among authors: chen w. Biochem Pharmacol. 2020 Jul;177:114000. doi: 10.1016/j.bcp.2020.114000. Epub 2020 Apr 28. Biochem Pharmacol. 2020. PMID: 32353424

2

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.

Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J. Wu D, et al. Among authors: chen w, chen y. Haematologica. 2018 Sep;103(9):1472-1483. doi: 10.3324/haematol.2018.188185. Epub 2018 Jun 7. Haematologica. 2018. PMID: 29880605 Free PMC article.

3

Microsecond molecular dynamics simulation of Aβ42 and identification of a novel dual inhibitor of Aβ42 aggregation and BACE1 activity.

Wang YY, Li L, Chen TT, Chen WY, Xu YC. Wang YY, et al. Acta Pharmacol Sin. 2013 Sep;34(9):1243-50. doi: 10.1038/aps.2013.55. Epub 2013 Jun 17. Acta Pharmacol Sin. 2013. PMID: 23770985 Free PMC article.

4

Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons.

Chen YT, Chen WY, Huang XT, Xu YC, Zhang HY. Chen YT, et al. Acta Pharmacol Sin. 2018 Feb;39(2):177-183. doi: 10.1038/aps.2017.113. Epub 2017 Aug 24. Acta Pharmacol Sin. 2018. PMID: 28836584 Free PMC article.

5

Structure-Based Discovery of PDEs Inhibitors.

Li L, Chen W, Chen T, Ren J, Xu Y. Li L, et al. Among authors: chen t, chen w. Curr Top Med Chem. 2016;16(9):917-33. doi: 10.2174/1568026615666150825142134. Curr Top Med Chem. 2016. PMID: 26303429 Review.

6

Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors.

Liu Q, Chen X, Chen W, Yuan X, Su H, Shen J, Xu Y. Liu Q, et al. Among authors: chen w, chen x. J Med Chem. 2016 May 26;59(10):5115-20. doi: 10.1021/acs.jmedchem.6b00282. Epub 2016 Apr 26. J Med Chem. 2016. PMID: 27078579

7

L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells.

Lu Q, Chen WY, Zhu ZY, Chen J, Xu YC, Kaewpet M, Rukachaisirikul V, Chen LL, Shen X. Lu Q, et al. Acta Pharmacol Sin. 2012 Dec;33(12):1459-68. doi: 10.1038/aps.2012.74. Epub 2012 Jul 30. Acta Pharmacol Sin. 2012. PMID: 22842730 Free PMC article.

8

Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors.

Zou Y, Li L, Chen W, Chen T, Ma L, Wang X, Xiong B, Xu Y, Shen J. Zou Y, et al. Among authors: chen t, chen w. Molecules. 2013 May 16;18(5):5706-22. doi: 10.3390/molecules18055706. Molecules. 2013. PMID: 23681056 Free PMC article.

9

A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain.

Zhang H, Zhou C, Chen W, Xu Y, Shi Y, Wen Y, Zhang N. Zhang H, et al. Among authors: chen w. Sci Rep. 2015 Apr 13;5:9542. doi: 10.1038/srep09542. Sci Rep. 2015. PMID: 25867902 Free PMC article.

10

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Zhang X, Dong G, Li H, Chen W, Li J, Feng C, Gu Z, Zhu F, Zhang R, Li M, Tang W, Liu H, Xu Y. Zhang X, et al. Among authors: chen w. J Med Chem. 2019 Jun 13;62(11):5579-5593. doi: 10.1021/acs.jmedchem.9b00518. Epub 2019 May 31. J Med Chem. 2019. PMID: 31099559

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