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347 results

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Page 1
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Buckley BJ, Aboelela A, Majed H, Bujaroski RS, White KL, Powell AK, Wang W, Katneni K, Saunders J, Shackleford DM, Charman SA, Cook GM, Kelso MJ, Ranson M. Buckley BJ, et al. Among authors: powell ak. Bioorg Med Chem. 2021 May 1;37:116116. doi: 10.1016/j.bmc.2021.116116. Epub 2021 Mar 23. Bioorg Med Chem. 2021. PMID: 33799173
Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.
Ogunniyi AD, Khazandi M, Stevens AJ, Sims SK, Page SW, Garg S, Venter H, Powell A, White K, Petrovski KR, Laven-Law G, Tótoli EG, Salgado HR, Pi H, Coombs GW, Shinabarger DL, Turnidge JD, Paton JC, McCluskey A, Trott DJ. Ogunniyi AD, et al. PLoS One. 2017 Sep 5;12(9):e0183457. doi: 10.1371/journal.pone.0183457. eCollection 2017. PLoS One. 2017. PMID: 28873428 Free PMC article.
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.
Hung LW, Villemagne VL, Cheng L, Sherratt NA, Ayton S, White AR, Crouch PJ, Lim S, Leong SL, Wilkins S, George J, Roberts BR, Pham CL, Liu X, Chiu FC, Shackleford DM, Powell AK, Masters CL, Bush AI, O'Keefe G, Culvenor JG, Cappai R, Cherny RA, Donnelly PS, Hill AF, Finkelstein DI, Barnham KJ. Hung LW, et al. Among authors: powell ak. J Exp Med. 2012 Apr 9;209(4):837-54. doi: 10.1084/jem.20112285. Epub 2012 Apr 2. J Exp Med. 2012. PMID: 22473957 Free PMC article.
Simplified silvestrol analogues with potent cytotoxic activity.
Hawkins BC, Lindqvist LM, Nhu D, Sharp PP, Segal D, Powell AK, Campbell M, Ryan E, Chambers JM, White JM, Rizzacasa MA, Lessene G, Huang DC, Burns CJ. Hawkins BC, et al. Among authors: powell ak. ChemMedChem. 2014 Jul;9(7):1556-66. doi: 10.1002/cmdc.201400024. Epub 2014 Mar 27. ChemMedChem. 2014. PMID: 24677741
Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).
Zheng Z, Pinson JA, Mountford SJ, Orive S, Schoenwaelder SM, Shackleford D, Powell A, Nelson EM, Hamilton JR, Jackson SP, Jennings IG, Thompson PE. Zheng Z, et al. Eur J Med Chem. 2016 Oct 21;122:339-351. doi: 10.1016/j.ejmech.2016.06.010. Epub 2016 Jun 10. Eur J Med Chem. 2016. PMID: 27387421
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.
Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Gummer JPA, Olasz B, Nambiar S, Hope DE, Casey TH, Lee YCG, Leslie C, Nealon G, Shackleford DM, Powell AK, Grimaldi M, Balaguer P, Zemek RM, Bosco A, Piggott MJ, Vrielink A, Lake RA, Lesterhuis WJ. Orozco Morales ML, et al. Among authors: powell ak. iScience. 2021 Dec 4;25(1):103571. doi: 10.1016/j.isci.2021.103571. eCollection 2022 Jan 21. iScience. 2021. PMID: 34984327 Free PMC article.
347 results